Evidence map›Paper›PMID 42804094›Full record

ArticleBulletin of experimental biology and medicine2026

Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C.

E I Safonova, Yu A Romanov, E A Tyrina

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

E I SafonovaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Yu A RomanovNational Medical Research Centre of Cardiology Named after Academician E. I. Chazov, Ministry of Health of the Russian Federation, Moscow, Russia.
E A TyrinaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. eagolikovamsu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studying stress-induced senescence of umbilical cord-derived mesenchymal stromal cells (UCMSCs) is important for ensuring the safety of their application in regenerative medicine. This study provides a comprehensive analysis of senescence features in UC-MSCs 7 days after treatment with mitomycin C (1.5 μg/mL). Despite the accumulation of DNA double-strand breaks (γH2AX/53BP1 foci) and complete proliferation arrest (the absence of Ki‑67

Indexed as

Cellular SenescenceMesenchymal Stem CellsMitomycinUmbilical CordCell Cycle CheckpointsCell ProliferationCells, CulturedCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27HumansOxidative StressSenescence-Associated Secretory PhenotypeTumor Suppressor Protein p53Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27MitomycinTumor Suppressor Protein p53mitomycin Cp53/p21 pathwaystress-induced senescenceumbilical cord mesenchymal stromal cells (UC-MSCs)

Identifiers

PMID42804094

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.