Evidence map›Paper›PMID 42804072›Full record

ArticleDrugs & aging2026

Risk of Dementia With Renin-Angiotensin System Inhibitors Versus Calcium Channel Blockers in Hypertensive Adults: A Nationwide Multicenter Study.

Yinfang Sun, Zhixin Guo, Jinming Zhang, Mingzhen Pang, Ruixuan Chen, Caoxiang She, Shiyu Zhou, Hao Wang, Xian Shao, Sheng Nie

Abstract read
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In one paragraph

Article in Drugs & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yinfang Sun *Division of Nephrology, Nanfang Hospital, National Clinical Research Center for Kidney and Urological Diseases, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, No. 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510510, China.
Zhixin Guo *Division of Nephrology, Nanfang Hospital, National Clinical Research Center for Kidney and Urological Diseases, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, No. 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510510, China.
Jinming Zhang *The First Clinical College, Dalian Medical University, Liaoning, China.
Mingzhen PangDivision of Nephrology, Nanfang Hospital, National Clinical Research Center for Kidney and Urological Diseases, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, No. 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510510, China.
Ruixuan ChenDivision of Nephrology, Nanfang Hospital, National Clinical Research Center for Kidney and Urological Diseases, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, No. 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510510, China.
Caoxiang SheDivision of Nephrology, Nanfang Hospital, National Clinical Research Center for Kidney and Urological Diseases, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, No. 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510510, China.
Shiyu ZhouDivision of Nephrology, Nanfang Hospital, National Clinical Research Center for Kidney and Urological Diseases, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, No. 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510510, China.
Hao WangNanfang Hospital, Southern Medical University, Guangzhou, China. mr_whouse@163.com.
Xian ShaoDivision of Nephrology, Nanfang Hospital, National Clinical Research Center for Kidney and Urological Diseases, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, No. 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510510, China. shaoxian@tmu.edu.cn.
Sheng NieDivision of Nephrology, Nanfang Hospital, National Clinical Research Center for Kidney and Urological Diseases, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, No. 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510510, China. niesheng0202@126.com.ORCID http://orcid.org/0000-0002-8267-7909

Funding

National Key R&D Program of China 2021YFC2500200National Key R&D Program of China 2021YFC2500204
6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate whether renin-angiotensin system inhibitors (RASIs) reduce dementia risk independently of blood pressure control compared with calcium channel blockers (CCBs) in antihypertensive-naïve adults with hypertension.

methodsThis multicenter, new-user active comparator study included antihypertensive-naïve adults initiating RASIs or CCBs across 28 hospitals. Participants were matched 1:1 on baseline characteristics using propensity score matching (PSM). The primary outcome was incident all-cause dementia; secondary outcomes were Alzheimer's disease and vascular dementia. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression.

resultsOf 164,918 eligible patients (median age 65 years [interquartile range 55-74]; 51.2% male), 54,042 PSM pairs initiating RASIs versus CCBs were included. During a median follow-up of 516 days, 344 incident dementia cases occurred. The incidence rate of all-cause dementia was lower among RASI initiators than CCB initiators (1.26 vs 1.89 per 1000 person-years). Initiation of RASIs was associated with a significantly lower risk of all-cause dementia (HR 0.68, 95% CI 0.55-0.84) and Alzheimer's disease (HR 0.59, 95% CI 0.43-0.81), but not vascular dementia (HR 0.74, 95% CI 0.50-1.11), compared with CCBs. There was no significant difference in dementia risk between initiators of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs).

conclusionsIn adults with hypertension, initiation of RASIs was associated with a significantly lower risk of dementia compared with CCBs. No significant difference was observed between ACEIs and ARBs. Further validation is warranted.

Identifiers

PMID42804072

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