Evidence map›Paper›PMID 42804059›Full record

ArticleWorld journal of microbiology & biotechnology2026

Protective effect of Glutamicibacter sp. ZY1 against Vibrio parahaemolyticus YDE17 pathogenicity in the clam Ruditapes philippinarum.

Yuanyuan Huang, Huili Hong, Tingting Li, Jian Zhang, Kai Liao, Jilin Xu, Weiwei Zhang

Abstract read
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In one paragraph

Article in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanyuan HuangSchool of Marine Sciences, Ningbo University, Ningbo, 315832, P. R. China.
Huili HongSchool of Marine Sciences, Ningbo University, Ningbo, 315832, P. R. China.
Tingting LiSchool of Marine Sciences, Ningbo University, Ningbo, 315832, P. R. China.
Jian ZhangSchool of Ocean, Yantai University, Yantai, 264005, P. R. China.
Kai LiaoSchool of Marine Sciences, Ningbo University, Ningbo, 315832, P. R. China.
Jilin XuSchool of Marine Sciences, Ningbo University, Ningbo, 315832, P. R. China.
Weiwei ZhangSchool of Marine Sciences, Ningbo University, Ningbo, 315832, P. R. China. zhangweiwei1@nbu.edu.cn.ORCID https://orcid.org/0000-0002-5678-2051

Funding

Major Project of Science, Technology and Innovation 2025 in Ningbo City 2021Z007Major Project of Science, Technology and Innovation 2035 in Ningbo City 2024Z276National Natural Science Foundation of China 42376103
6 · The paper itself

Abstract

The use of probiotics is preferable to the use of antibiotics for the control of vibriosis. In this study, artificial infection showed that Glutamicibacter sp. ZY1 significantly protected the Manila clam Ruditapes philippinarum from infection by Vibrio parahaemolyticus YDE17, with a relative percent survival of 82.16%. Glutamicibacter sp. ZY1 significantly reduced the total numbers of culturable Vibrio and V. parahaemolyticus in the infected clam R. philippinarum. Histopathological observation revealed that the pathological damage to the gills of individuals infected by V. parahaemolyticus YDE17 was alleviated by Glutamicibacter sp. ZY1. Furthermore, preinoculation with Glutamicibacter sp. ZY1 inhibited the biofilm formation of V. parahaemolyticus YDE17. Transcriptomic analysis revealed that V. parahaemolyticus YDE17 downregulated genes related to the immune response and peptide cross-linking in the clam R. philippinarum, and inhibited β-alanine metabolism and fatty acid degradation. Glutamicibacter sp. ZY1 activated the immune response, oxidative stress response, and heme/tetrapyrrole binding, and it upregulated pathways involved in arachidonic acid metabolism, arginine and proline metabolism, and the folate-mediated one-carbon pool. Glutamicibacter sp. ZY1 alleviated immune suppression and upregulated steroid hormone biosynthesis and linoleic acid metabolism. Taken together, Glutamicibacter sp. ZY1 shows promise as a probiotic candidate for protecting the clam R. philippinarum against Vibrio infection.

Indexed as

BivalviaProbioticsVibrio InfectionsVibrio parahaemolyticusAnimalsBiofilmsGene Expression ProfilingGillsVirulenceAntagonistClam Ruditapes philippinarumGlutamicibacter sp.Transcriptomic analysisVibrio parahaemolyticus

Identifiers

PMID42804059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.