High-yield reactor production of terbium-161 using thin-layer gadolinium-160 targets, simplified chloride based separation and radiolabeling of DOTA based ligands.

Shakera Khatoon, Amna Javed, Qaiser Khan, Kaleem Abbas

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Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

4 authors.

Shakera KhatoonDepartment of Radiologic Technology, College of Applied Medical Sciences, Qassim University, Al-Maleda, Buraydah, 52571, Al-Qassim, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0001-8316-7065

Amna JavedIsotope Production Division, Pakistan Institute of Nuclear Science and Technology (PINSTECH), Nilore, Islamabad, P.O Box 7 45650, Pakistan.

Qaiser KhanIsotope Production Division, Pakistan Institute of Nuclear Science and Technology (PINSTECH), Nilore, Islamabad, P.O Box 7 45650, Pakistan.

Kaleem AbbasDepartment of Materials, National Institute of Laser and Optronics, Nilore, Islamabad, P.O Box 21 45650, Pakistan. s.abbas@qu.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTerbium-161 (

resultsThin-layer targets significantly enhanced neutron utilization, compared to oxide targets due to reduced self-shielding of target. The specific activities achieved across three production batches (34.25-79.01 MBq/mg) demonstrated an approximately 2.3-fold higher specific activity with

conclusionTarget geometry plays a critical role in reactor-based radionuclide production. The integrated thin-layer target and chloride-based separation workflow provides a simplified, high-yield approach for production of terbium-161, enables efficient radiolabeling with DOTA-based ligands. These findings provide a foundation for further analytical qualification required for preclinical and clinical translations.

Indexed as

Auger electronExtraction chromatographyRadiolanthanidesTerbium-161Thin-layer targets

Identifiers

PMID42804046

DOI10.1016/j.apradiso.2025.112144

PMCPMC13620108

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