ArticleClinical oral investigations2026
Saturated anacardic acid preserves root dentin collagen under cariogenic challenge.
Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveWe aimed to evaluate changes in the structure and organization of root dentin collagen in bovine incisors pre-treated with an anacardic acid derivative (LDT11) following an in vitro cariogenic challenge, thereby contributing to understanding of dentin matrix biology and biomodification strategies for root caries management. MATERIALS AND
methodsBovine root dentin specimens were demineralized and pre-treated with LDT11 (100 µg/mL) or distilled water (control). Samples were then subjected to a cariogenic challenge for 7 days. Histological sections were stained with Picrosirius and analyzed by polarized light microscopy to assess collagen organization and residual collagen area. Additional analyses were performed using Fourier Transform Infrared Spectroscopy in Attenuated Total Reflectance mode (FTIR-ATR) and thermogravimetric analysis (TGA).
resultsLDT11-pretreated samples showed a significantly greater residual collagen area compared to controls (p < 0.01), with preservation of a dense and organized fibrillar network. FTIR-ATR analysis revealed spectral changes consistent with hydrogen bonding and collagen biomodification. Principal component analysis demonstrated clear separation between treated and untreated groups. In contrast, TGA showed no significant differences in total collagen mass loss, suggesting a localized effect of LDT11 at the superficial dentin layer.
conclusionLDT11 promotes preservation of the dentin collagen matrix under cariogenic challenge and exhibits potential as a collagen biomodifier through chemical interaction with the organic matrix. Its effects appear to be primarily surface-oriented, contributing to structural stability without altering collagen mass. CLINICAL RELEVANCE: Potential of LDT11 as a dentin-interacting agent that can help control collagenolytic degradation as an adjunct for managing root caries lesions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.