ArticleWorld journal of urology2026
Biopsy and identification of risk factors for discordance in renal tumor: results from the BIRD study (UroCCR n°230).
Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the rate of histological discordance between renal mass biopsy(RMB) and final surgical pathology in patients with localized renal tumors, and to identify risk factors of discordance. MATERIALS AND
methodsThe BIRD study is a retrospective multicenter analysis conducted within the prospective UroCCR database between February 2004 and January 2025. We included all patients who underwent a renal mass biopsy followed by surgical treatment(partial or radical nephrectomy). The primary endpoint was the histological discordance rate, defined as a mismatch in tumor type between the biopsy and the surgical specimen, or a non-diagnostic biopsy, and diagnostic accuracy. Univariate and multivariate logistic regression analyses were performed to identify factors associated with discordance.
resultsA total of 1,301 patients from 19 centers were included, with 65% male and a median age of 63 years(51-71). Tumors were equally distributed between the right and left kidneys, with a median size of 3.7 cm(2.5-5.0). Final histology showed 8% benign and 92% malignant tumors. Tumor necrosis was found in 23% of cases. Among tumors assessed for nuclear grade, a 48% discordance was observed between low(ISUP1-2) and high grades(ISUP3-4). Overall, the histological discordance rate was 18%, including 3.7% for malignancy diagnosis, 8.4% for histological subtype, and 5.7% for non-diagnostic biopsies. On multivariable analysis after multiple imputation, cystic tumor(OR 2.18, 95%CI 1.23-3.85, p = 0.007) was independently associated with increased risk of histological discordance. Moderate and high R.E.N.A.L. score complexity were associated with reduced discordance risk(OR 0.67, 95%CI 0.47-0.96, p = 0.03 and OR 0.60, 95%CI 0.37-0.98, p = 0.04, respectively).
conclusionsRMB provided a high diagnostic yield but was associated with an overall 18% discordance rate. Cystic tumors were the only independent factor associated with an increased risk of discordance, while tumor complexity and size influenced discordance subtypes. Regarding ISUP grade, RMB showed imperfect reliability, failing to reflect true tumor aggressiveness in nearly half of discordant cases.
Indexed as
Identifiers
42803961What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.