Evidence map›Paper›PMID 42803936›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

A FABulous approach to image human macrophages.

Borna Roohani, Ayla Vaughn Embs, Robin Kumar, Supum Lee, Samantha R Katz, Chloe La Prairie, Dajah Nash, Mann Dangarwala, Harriet M Kluger, Daryl E Klein and 4 more

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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Borna Roohani *Department of Radiology, University of Alabama at Birmingham, 1824 6th Ave. S., Wallace Tumor Institute 310C, Birmingham, AL, 35233, USA.
Ayla Vaughn Embs *Department of Radiology, University of Alabama at Birmingham, 1824 6th Ave. S., Wallace Tumor Institute 310C, Birmingham, AL, 35233, USA.ORCID http://orcid.org/0009-0006-7055-0413
Robin KumarDepartment of Radiology, University of Alabama at Birmingham, 1824 6th Ave. S., Wallace Tumor Institute 310C, Birmingham, AL, 35233, USA.
Supum LeeDepartment of Radiology and Biomedical Imaging, Yale PET Center, Yale University, New Haven, CT, USA.
Samantha R KatzDepartment of Radiology and Biomedical Imaging, Yale PET Center, Yale University, New Haven, CT, USA.
Chloe La PrairieDepartment of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Dajah NashDepartment of Radiology, University of Alabama at Birmingham, 1824 6th Ave. S., Wallace Tumor Institute 310C, Birmingham, AL, 35233, USA.
Mann DangarwalaDepartment of Radiology, University of Alabama at Birmingham, 1824 6th Ave. S., Wallace Tumor Institute 310C, Birmingham, AL, 35233, USA.
Harriet M KlugerDepartment of Medicine, Yale University, New Haven, CT, USA.
Daryl E KleinDepartment of Pharmacology, Yale University, New Haven, CT, USA.
Ping ZhangDepartment of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Benjamin M LarimerDepartment of Radiology, University of Alabama at Birmingham, 1824 6th Ave. S., Wallace Tumor Institute 310C, Birmingham, AL, 35233, USA.
Bryce NelsonOrion Pharma, Cambridge, UK.
Bernadette Marquez-NostraDepartment of Radiology, University of Alabama at Birmingham, 1824 6th Ave. S., Wallace Tumor Institute 310C, Birmingham, AL, 35233, USA. bmarqueznostra@uabmc.edu.ORCID http://orcid.org/0000-0001-9024-0750

Funding

Development of novel human Fab probes for PET imaging of macrophagesR01EB031821 · NIBIB · YALE UNIVERSITY · PI MARQUEZ-NOSTRA, BERNADETTE · 2021 to 2024
$2.3M
NIBIB NIH HHS R01EB031821
6 · The paper itself

Abstract

rationaleImaging tumor-associated macrophages (TAMs) may reflect prognosis, therapeutic response and radiotheranostic potential. We report the discovery and development of a synthetic human Fab as the first immunoPET tracer targeting human CD68 (huCD68), the gold standard histopathological biomarker of pan-macrophages.

methodsPhage display was used to identify novel huCD68-specific Fabs. The lead Fab for immunoPET development was chosen based on expression yield and stability. Fab was conjugated to p-SCN-Bn-DFO and radiolabeled with

resultsFour novel huCD68-specific Fabs were identified. Fab8 was chosen as the lead based on high expression yield, purity, and stability. In vivo, [

conclusion[

Indexed as

CD68FabImmunoPETMacrophagesPhage display

Identifiers

PMID42803936

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.