Evidence map›Paper›PMID 42803928›Full record

ArticleSurgery today2026

Association between Clostridium septicum and Streptococcus gallolyticus bacteremia and colorectal neoplasms.

Shinnosuke Kai, Takashi Ueda, Kazuhiko Nakajima, Miki Doi, Hitoshi Ogashiwa, Masanori Uno, Akiko Okada, Masaya Nakashima, Mayuko Fujisawa, Hiroyuki Watanabe and 11 more

Abstract read
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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Shinnosuke KaiDepartment of Infection Prevention and Control, Chita Peninsula General Medical Organization, Rinku Hospital, 3-3-3 Asukadai, Tokoname, 479-8510, Aichi, Japan.
Takashi UedaDepartment of Infection Prevention and Control, Hyogo Medical University Hospital, Nishinomiya, Japan.
Kazuhiko NakajimaDepartment of Infection Prevention and Control, Hyogo Medical University Hospital, Nishinomiya, Japan.
Miki DoiDepartment of Clinical Technology, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Hitoshi OgashiwaDepartment of Clinical Technology, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Masanori UnoDepartment of Surgery, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Akiko OkadaDepartment of Surgery, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Masaya NakashimaDepartment of Surgery, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Mayuko FujisawaDepartment of Surgery, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Hiroyuki WatanabeDepartment of Surgery, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Yasushi TakenouchiDepartment of Surgery, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Kosuke IijimaDepartment of Clinical Technology, Hyogo Medical University Hospital, Nishinomiya, Japan.
Shinichiro ShinzakiDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Japan.
Nobuko ImamuraDepartment of Gastroenterology, Hyogo Medical University School of Medicine, Nishinomiya, Japan.
Kozo KataokaDivision of lower GI, Department of Gastroenterological surgery, Hyogo Medical University, Nishinomiya, Japan.
Kei KimuraDivision of lower GI, Department of Gastroenterological surgery, Hyogo Medical University, Nishinomiya, Japan.
Motoi UchinoDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University, Nishinomiya, Japan.
Yuki HorioDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University, Nishinomiya, Japan.
Ryuichi KuwaharaDivision of Inflammatory Bowel Disease Surgery, Department of Gastroenterological Surgery, Hyogo Medical University, Nishinomiya, Japan.
Yasuhiro NozakiDepartment of Respiratory Medicine, Chita Peninsula General Medical Organization, Rinku Hospital, Tokoname, Japan.
Yoshio TakesueDepartment of Infection Prevention and Control, Chita Peninsula General Medical Organization, Rinku Hospital, 3-3-3 Asukadai, Tokoname, 479-8510, Aichi, Japan. takesuey@hyo-med.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeColorectal cancer (CRC) is associated with Clostridium septicum (CS), Streptococcus gallolyticus (SG), and Fusobacterium nucleatum (FN) bacteremia. Further investigation of the mechanism of translocation and the time interval between bacteremia and a CRC diagnosis is required.

methodsPatients with bacteremia caused by the three organisms were studied. The organisms were identified using MALDI-TOF mass spectrometry.

resultsFourteen patients (CS [n = 1], SG [n = 11], and FN [n = 2]) were included among 2866 patients with bacteremia. Colorectal neoplasms were detected in two patients at the onset of bacteremia (advanced CRC in patient CS and carcinoma in adenoma in patient SG). Rectal cancer developed 31 months after incidental bacteremia in another patient with SG. Colonoscopy was not performed in 10 of 14 patients, including two patients with FN at the onset of bacteremia and during the follow-up period.

conclusionConsistent with previous reports, we found three typical patterns associated with CRC in patients with CS and SG bacteremia. Because routine colonoscopy was not performed, the true association with CRC could not be determined for these organisms.

Indexed as

BacteremiaCarcinogenesisClostridium septicumColorectal cancerStreptococcus gallolyticus

Identifiers

PMID42803928

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.