Evidence map›Paper›PMID 42803916›Full record

ArticleProbiotics and antimicrobial proteins2026

Antifungal Potential of Peptide-Enriched Fractions Isolated from Capsicum frutescens Seeds Against Yeasts of the Genus Candida.

Layrana de Azevedo Dos Santos, Marciele Souza da Silva, Gabriel Bonan Taveira, Vitor Batista Pinto, Marcos Paulo Da Conceição Moura Silva, Gabriella Rodrigues Gonçalves, André de Oliveira Carvalho, Rosana Rodrigues, Valdirene Moreira Gomes

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Layrana de Azevedo Dos SantosLaboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Marciele Souza da SilvaLaboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Gabriel Bonan TaveiraLaboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Vitor Batista PintoLaboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Marcos Paulo Da Conceição Moura SilvaLaboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Gabriella Rodrigues GonçalvesLaboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
André de Oliveira CarvalhoLaboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Rosana RodriguesLaboratório de Melhoramento e Genética Vegetal, Centro de Ciências e Tecnologias Agropecuárias, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Valdirene Moreira GomesLaboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil. valmguenf@gmail.com.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307590/2021-6FAPERJ E-26/200.127/2023Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/210353/2022
6 · The paper itself

Abstract

The increasing emergence of drug-resistant fungal pathogens has heightened the search for new antimicrobial compounds with previously unexplored modes of action. Among candidate molecules for control of fungal diseases, plant antimicrobial peptides (AMPs) have attracted considerable interest because they are natural molecules with broad-spectrum inhibitory activities against microorganisms. In this study, peptide-enriched fractions obtained from Capsicum frutescens seeds were evaluated for antimicrobial activity and mechanisms of action against Candida species. Hemotoxicity was evaluated in vitro using sheep erythrocyte lysis, and inhibitory effects against serine protease and α-amylase enzymes were also determined. Initially, the protein-rich extract obtained was fractionated by reverse-phase chromatography on an HPLC system, resulting in five major fractions (F1-F5). Enzymatic assay revealed that all these fractions inhibited the activity of human salivary α-amylase, with F2 exhibiting 100% inhibition of activity. Fractions F2 and F3 exhibited the highest antifungal activity, inhibiting the growth of Candida albicans by 83% and 69% and Candida parapsilosis by 71% and 57%, respectively (200 µg mL

Indexed as

AMPsAnti-Candida activityCapsicum frutescens seedsPlant defense

Identifiers

PMID42803916

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.