Evidence map›Paper›PMID 42803886›Full record

ArticleEndocrine2026

Exploration of cytokines relating to masked obesity in Japanese women.

Chisaki Ishibashi, Kaori Nakanishi, Makoto Nishida, Kiyoshi Masuyama, Maki Shinzawa, Daisuke Kanayama, Ryohei Yamamoto, Toshiki Moriyama, Izumi Nagatomo, Keiko Yamauchi-Takihara

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Article in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chisaki IshibashiHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.
Kaori NakanishiHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan. nakanishi.kaori.chw@osaka-u.ac.jp.
Makoto NishidaHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.
Kiyoshi MasuyamaHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.
Maki ShinzawaHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.
Daisuke KanayamaHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.
Ryohei YamamotoHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.
Toshiki MoriyamaHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.
Izumi NagatomoHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.
Keiko Yamauchi-TakiharaHealth Care Division, Health and Counseling Center, The University of Osaka, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMasked obesity (MO) has been associated with chronic inflammation; however, its immunological profile has not been extensively studied.

objectiveThis exploratory study aimed to investigate immunological profile in MO by examining serum cytokine levels and clinical characteristics in individuals with reduced muscle mass and increased fat.

methodsBody composition was assessed in 432 female employees of The University of Osaka (aged 30-59 years) using InBody270 during health examinations. Participants with skeletal muscle mass index (SMI) ≥ 5.7 kg/m² and percent body fat (PBF) < 30% were classified as the healthy (H) group, while those with SMI < 5.7 kg/m² and PBF ≥ 30% were classified as the MO group. Serum cytokine concentrations were measured in randomly selected participants, 34 from the H group and 24 from the MO group.

resultsCompared to the H group, the MO group had significantly higher triglyceride (p < 0.0001), low-density lipoprotein cholesterol (p = 0.0047), and insulin (p = 0.0008) levels, and significantly lower grip strength (p < 0.0001). Interleukin-17 C levels (unadj. p = 0.017, q = 0.33), colony-stimulating factor-1 (unadj. p = 0.051, q = 0.33) and lymphotoxin-alpha (unadj. p = 0.053, q = 0.33) levels tended to be lower, and interleukin-6 (unadj. p = 0.049, q = 0.33), C-C motif chemokine ligand (CCL) 8 (unadj. p = 0.064, q = 0.33) and CCL2 (unadj. p = 0.066, q = 0.33) levels tended to be higher in the MO group than in the H group.

conclusionThis exploratory study demonstrates that MO might be associated with circulating levels of some cytokines, suggesting that these cytokines could be potential biomarkers for MO.

Indexed as

CytokinesObesity, Metabolically BenignAdultBody CompositionEast Asian PeopleFemaleHumansJapanMiddle AgedMuscle, SkeletalCytokinesBody compositionChronic inflammationCytokinesHidden obesityMasked obesityNormal-weight obesitySarcopenia

Identifiers

PMID42803886
PMCPMC13619796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.