Outcomes of Embryo Transfer Following Laser-assisted Hatching in Patients with Recurrent Implantation Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Mohammadamin Parsaei, Elaheh Karimi, Parsa Seifi, Masoumeh Dehghan Tarzjani, Azadeh Tarafdari

Abstract readReview

In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammadamin ParsaeiBreastfeeding Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Elaheh KarimiTehran Heart Center, Cardiovascular Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Parsa SeifiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Masoumeh Dehghan TarzjaniDepartment of Obstetrics and Gynecology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Postal Code: 1419733141, Iran.

Azadeh TarafdariDepartment of Obstetrics and Gynecology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Postal Code: 1419733141, Iran. tarafdari@tums.ac.ir.ORCID http://orcid.org/0000-0003-4591-9507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent implantation failure (RIF) affects approximately 10% of women undergoing embryo transfer. While laser-assisted hatching (LAH) has been proposed to improve outcomes, its efficacy remains uncertain in RIF patients. This study evaluated whether LAH improves outcomes for women with RIF. A systematic review was conducted in PubMed, Web of Science, Scopus, and Embase on January 22, 2025, for randomized controlled trials comparing embryo transfer outcomes following LAH versus controls in RIF. Random-effects meta-analyses generated log odds ratios (LOR), with evidence certainty graded using the Grading of Recommendations Assessment, Development and Evaluation tool. Nine studies involving 2,481 women with RIF were included. Meta-analysis revealed significantly higher rates in the LAH group compared to controls for clinical pregnancy (LOR = 0.643 [0.267, 1.019]; I

Indexed as

Embryo implantationEmbryo transferIn-vitro fertilizationLaser-assisted hatchingRecurrent implantation failure

Identifiers

PMID42803876

DOI10.3389/frph.2025.1581529

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.