Evidence map›Paper›PMID 42803869›Full record

ArticleMolecular and cellular biochemistry2026

ANKRD28 interacts with DOCK180 to activate Rac1-STAT3-Myc signaling and sustain stemness of CD34

Xiaoyan Zheng, Yue Du, Xiaohui Zhang, Huachao Zhu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaoyan Zheng *Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, Shaanxi, China.
Yue Du *Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, Shaanxi, China.
Xiaohui ZhangDepartment of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, Shaanxi, China.
Huachao ZhuDepartment of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, Shaanxi, China. zhuhuachao@xjtufh.edu.cn.

Funding

Innovation Capacity Support Program of Shaanxi Province 2022-XKCRC-03Shaanxi Province Key Research and Development Project 2025SF-YBXM-301
6 · The paper itself

Abstract

Leukemia stem cell (LSC) stemness maintenance is a core cause of relapse and therapeutic resistance in acute myeloid leukemia (AML). ANKRD28, an ankyrin repeat domain‑containing gene, has been implicated in malignant phenotypes across various tumors, but its role in regulating AML LSC stemness remains unclear. GEO datasets (GSE9476, GSE30029) and public databases (GEPIA2, TIMER, CCLE) were analyzed to characterize ANKRD28 expression and prognostic relevance in AML and LSCs. ANKRD28 expression in CD34

Indexed as

Acute myeloid leukemiaAnkyrin repeat domain 28Dedicator of cytokinesis 180Leukemia stem cellsRac1‑STAT3‑Myc axisStemness maintenance

Identifiers

PMID42803869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.