ArticleMikrochimica acta2026
DNAzyme assisted self-feedback electrochemiluminescence signal amplification for the detection of miRNA-622.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A novel microRNA (miRNA-622) biosensor platform was constructed based on nano-confined effect of vertically-ordered mesoporous silica film (VMSF) and self-feedback cascade amplification strategy of DNAzyme. VMSF was grown in-situ on the ITO electrode surface, which could effectively block the interference of biological matrix and enrich the luminophore by its nano-confinement effect. Meanwhile, DNAzyme walking strands and ferrocene-labeled substrate strands were immobilized on the electrode surface through Au-S bonds, quenched the ECL signal and switched the signal-off. Upon the addition of target miRNA-622, the DNAzyme walker was activated and moved autonomously, completing substrate strand cleavage and signal-on with the assistance of Mg
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