Evidence map›Paper›PMID 42803830›Full record

ArticleClinical oral investigations2026

Time-dependent prognostic value of perioperative changes in the systemic inflammation response index for overall survival in oral tongue squamous cell carcinoma: a retrospective cohort study.

Silong Zhong, Bin Shi, Rongrong Fu, Qiuping Zhuo, Guohui Li, Yifan Xu, Jinteng Chen, Yu Qiu, Bingju Gao, Lisong Lin and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Silong Zhong *Stomatological Center, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Bin Shi *Stomatological Center, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Rongrong FuDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, No. 1 Xuefu North Road, Fuzhou, 350108, China.
Qiuping ZhuoDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, No. 1 Xuefu North Road, Fuzhou, 350108, China.
Guohui LiDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, No. 1 Xuefu North Road, Fuzhou, 350108, China.
Yifan XuDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, No. 1 Xuefu North Road, Fuzhou, 350108, China.
Jinteng ChenDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, No. 1 Xuefu North Road, Fuzhou, 350108, China.
Yu QiuStomatological Center, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Bingju GaoStomatological Center, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Lisong LinStomatological Center, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Jing WangLaboratory Center, School of Public Health, The Major Subject of Environment and Health of Fujian Key Universities, Fujian Medical University, Fuzhou, China.
Baochang HeStomatological Center, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China. hbc@fjmu.edu.cn.

Funding

Mutual Expert Research Project of the First Affiliated Hospital of Fujian Medical University YJRCHP-2023HBC
6 · The paper itself

Abstract

objectivesTo investigate the association between perioperative changes in the systemic inflammation response index (SIRI) and overall survival (OS) in patients with oral tongue squamous cell carcinoma (OTSCC), with a focus on its time-dependent prognostic value. MATERIALS AND

methodsThis single-center retrospective cohort study included 264 patients with primary OTSCC who underwent curative-intent resection between June 2015 and February 2025. ΔSIRI was defined as postoperative SIRI minus preoperative SIRI. Time-dependent receiver operating characteristic (ROC) analysis was used to derive the ΔSIRI cutoff. Survival analyses included Kaplan-Meier curves, Cox regression, restricted mean survival time (RMST), and time-varying coefficient Cox models.

resultsDuring follow-up, 70 deaths occurred. In multivariable Cox analysis, high ΔSIRI was significantly associated with poorer OS (adjusted hazard ratio [HR] = 2.13, 95% confidence interval [CI]: 1.24-3.67, P = 0.006). Adjusted RMST analysis showed an 8.02-month reduction in restricted mean survival time in the high ΔSIRI group within 60 months compared with the low ΔSIRI group (95% CI: - 12.76 to - 3.28, P < 0.001). The time-varying coefficient Cox model indicated that the adverse prognostic association of high ΔSIRI was most pronounced during the early follow-up period and gradually attenuated over time.

conclusionsHigh perioperative ΔSIRI was associated with poorer OS in patients with OTSCC. ΔSIRI may serve as an adjunctive dynamic inflammatory-immune marker for early postoperative risk stratification, although external validation is warranted. CLINICAL RELEVANCE: Perioperative ΔSIRI may provide supplementary information for identifying patients with OTSCC at higher early postoperative mortality risk.

Indexed as

Carcinoma, Squamous CellSquamous Cell Carcinoma of Head and NeckTongue NeoplasmsAgedFemaleHumansMaleMiddle AgedPerioperative PeriodPrognosisRetrospective StudiesROC CurveSurvival RateTime FactorsOral tongue squamous cell carcinomaOverall survivalRestricted mean survival timeSystemic inflammation response indexTime-varying associationΔSIRI

Identifiers

PMID42803830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.