ArticleJournal of Alzheimer's disease : JAD2026
Age-dependent associations between physical activity and cognitive function in adults aged 70-100: A cross-sectional and longitudinal study.
Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundWhile the protective effects of physical activity (PA) on cognitive function and risk for cognitive decline are well documented, it remains unclear if the preventive effect continues at advancing age.ObjectiveThis study aims to examine the association between PA and cognitive impairment between ages 70-100MethodsThe Jerusalem Cross-sectional and Longitudinal Study (1990-2023) prospectively follows a representative community-dwelling cohort born 1920-1921, combining follow-up of the original cohort with repeated recruitment of same-birth cohort participants at each age. During the study, assessments were performed at ages 70, 78, 85, 90, 95, and 100 (n = 604, 1024, 1222, 729, 508, 205, respectively). Comprehensive assessment included Mini-Mental State Examination (MMSE) defining cognitive impairment (≤23/30), and self-reported PA, dichotomized to Sedentary (PA-S) (<4 h weekly) versus Active (PA-A) (at least >4 h a week).ResultsAt ages 70, 78, 85, 90, 95, and 100 the frequency of PA-A was 53.5%, 77.0%, and declined to 64.3%, 16.0%, 25.5%, and 27.1%, respectively. In a longitudinal analysis, PA-S at baseline was found to have a statistically significant association with cognitive impairment at a later age between ages 78-85, 85-90: OR 2.61 (95%CI 1.38-4.82); OR 2.90 (95%CI 1.63- 5.11), respectively. At ages 90-95 a similar not statistically significant effect was found.ConclusionsPA is associated with better cognitive aging and lower risk for cognitive impairment in advanced age. Inclusion of very old adults extends evidence into an age rarely examined and demonstrates that promotion of PA remains relevant even at advanced ages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.