Observational studyHuman vaccines & immunotherapeutics2026
Efficacy and safety of radiofrequency hyperthermia combined with immune checkpoint inhibitors and chemotherapy as first-line treatment for HER2-negative advanced gastric/gastroesophageal junction adenocarcinoma: A propensity score-matched study.
Observational study in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
16 authors.
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Abstract
Radiofrequency hyperthermia (RFH) increases local tumor temperature and may enhance sensitivity to systemic therapies. We evaluated the association between adding RFH to first-line immune checkpoint inhibitor (ICI) plus chemotherapy and outcomes in patients with HER2-negative advanced gastric/gastroesophageal junction (GEJ) adenocarcinoma. This study adopted a single-center, retrospective, observational design. Patients treated between January 2021 and January 2024 were retrospectively enrolled and grouped by receipt of RFH (hyperthermia vs. non-hyperthermia). The primary endpoint was overall survival (OS); secondary endpoints were progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and safety. A 1:1 propensity score matching (PSM) analysis was performed. A total of 212 patients were included: 119 in the hyperthermia group and 93 in the non-hyperthermia group. In the overall cohort, RFH was associated with longer median PFS (10.17 vs. 7.06 months; HR = 0.70;
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