ArticleJournal of diabetes investigation2026
Metabolic health, independent of body mass index, is associated with mortality risk in type 1 diabetes.
Article in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
AIMS/
introductionAlthough a low body mass index (BMI) is traditionally associated with high mortality in type 1 diabetes (T1D), the increasing prevalence of obesity and its association with mortality warrant further research. MATERIALS AND
methodsUsing a nationwide Korean database from 2002 to 2018, we classified patients with T1D into six categories based on metabolic health and BMI (≥25, 18.5-25, and <18.5 kg/m
resultsAmong 8,838 patients with T1D (mean age 54.7 years, 60.6% male), the prevalence of MUUW, MHUW, MUNW, MHNW, MHO, and MUO was 1.1%, 3.0%, 28.5%, 31.2%, 6.3%, and 29.9%, respectively. Over a median 8.3-year follow-up, patients with MHO exhibited the lowest all-cause mortality risk (adjusted hazard ratio [aHR], 0.70; P = 0.007), and those with MUO also had a lower risk (aHR, 0.77; P < 0.001) compared with the MHNW group. Conversely, the underweight groups had significantly higher all-cause (MHUW: aHR, 2.08; MUUW: aHR, 3.94) and cardiovascular disease (CVD)-related mortalities (MHUW: aHR, 2.47; MUUW: aHR, 6.31). Patients with MHO had a lower risk of CVD (aHR, 0.76), whereas those with MUO, MUNW, and MUUW had increased risks (aHRs, 1.18, 1.32, and 2.22).
conclusionsMetabolic unhealthiness was associated with a higher CVD risk, and the risks of mortality and CVD were particularly high in patients with MUUW, underscoring the importance of maintaining metabolic health in T1D.
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