Evidence map›Paper›PMID 42803593›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

MN•CS•IO System: Cross-Species Study for HBB Function in High-Altitude Hypoxia Adaptation.

Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang and 9 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Wenqiao Hui *Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agriculture Sciences, Hefei, China.
Lin Mao *Center for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.
Binggang Li *Center for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.
Hanyue Kang *Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Key Laboratory of D&A for Metal-Functional Materials, School of Materials Science & Engineering, Tongji University, Shanghai, China.
Zhengquan TangCenter for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.ORCID https://orcid.org/0000-0003-1691-6358
Sheng ChenAnhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agriculture Sciences, Hefei, China.
Hui YangResearch Center for High Altitude Medicine, Qinghai University, Xining, China.ORCID https://orcid.org/0009-0001-2226-3392
Yu QiaoAnhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agriculture Sciences, Hefei, China.
Huiqian DingCenter for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.
Yuhuan WangResearch Center for High Altitude Medicine, Qinghai University, Xining, China.
Min LiCenter for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.
Junjie HuCenter for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.
Shoudong YeCenter for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.ORCID https://orcid.org/0000-0003-1864-8561
Xin WangCenter for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.ORCID https://orcid.org/0000-0001-5294-1126
Xiaobin XuKey Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Key Laboratory of D&A for Metal-Functional Materials, School of Materials Science & Engineering, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-3479-0130
Yupeng WangCollege of Resources and Environment, Anhui Agricultural University, Hefei, China.
Tana WurenResearch Center for High Altitude Medicine, Qinghai University, Xining, China.ORCID https://orcid.org/0000-0003-2695-4737
Qian BanCenter for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.ORCID https://orcid.org/0000-0002-3520-1721
Baowei ZhangCenter for Stem Cell and Translational Medicine, School of Life Sciences and Medical Engineering, Anhui University, Hefei, China.ORCID https://orcid.org/0000-0003-4289-4754

Funding

Anhui Province Key research and Development Project 202104e11020003Natural Science Foundation of Anhui Province 2208085MC51Natural Science Foundation of Anhui Province 2208085MC74Scientific Research Foundation from the Education Department of Anhui Province KJ2021A0055Youth Elite Project of Anhui Academy of Agricultural Sciences QNYC-202511
6 · The paper itself

Abstract

The genetic basis of high-altitude hypoxia adaptation remains largely elusive, particularly the role of HBB. Here, we developed an integrative mesh-nanorod (MN) cell sorting, chitosan nanoparticle (CS) delivery, and in vivo intraosseous (IO) injection (MN•CS•IO) system to functionally investigate HBB in cross-species high-altitude hypoxia adaptation. Using this MN•CS•IO platform, we transplanted high/low-altitude species HBB-modified lineage-negative (Lin

Indexed as

gene deliveryHBBhigh‐altitudehypoxia adaptationQinghai‐Tibet Plateau animals

Identifiers

PMID42803593
PMCPMC13618169

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.