ArticleApplied and environmental microbiology2026
PhpR, as a unique transcriptional regulator, represses the expression of pyridoxal 5'-phosphate-binding protein YggS in
Qimiao Xu, Changchang Wang, Jiaxi Liu, Fuyu Song, De-Feng Li, Jiasong Li, Shang Dai, Xin Yan, Qing Hong, Jiandong Jiang and 3 more
Abstract read
In one paragraphArticle in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Qimiao XuKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.
Changchang WangKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.
Jiaxi LiuKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.
Fuyu SongKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.
De-Feng LiState Key Laboratory of Microbial Resources, Environmental Microbiology Research Center at Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-8683-019X Jiasong LiKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.
Shang DaiKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.
Xin YanKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.ORCID 0000-0001-8658-7444 Qing HongKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.ORCID 0000-0001-5385-6281 Jiandong JiangKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.ORCID 0000-0003-4877-5756 Shuang-Jiang LiuState Key Laboratory of Microbial Resources, Environmental Microbiology Research Center at Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-7585-310X Jian HeKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.ORCID 0000-0002-8569-9265 Jiguo QiuKey Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, College of Life Sciences, Nanjing Agricultural University, Nanjing, China.ORCID 0000-0002-7633-6227 Funding
National Natural Science Foundation of China 32370041National Natural Science Foundation of China 32370128, 32570117National Natural Science Foundation of China 32570134, U23A20200National Natural Science Foundation of China 32570142
6 · The paper itselfAbstract
YggS (COG0325 family) was widely conserved across the three domains of life and had been implicated in pyridoxal 5'-phosphate (PLP) homeostasis. However, transcriptional regulators that directly controlled IMPORTANCE: Pyridoxal 5'-phosphate (PLP), the main catalytically active form of vitamin B6, was an essential cofactor for many enzymes, particularly those involved in amino acid metabolism. PLP deficiency could impair the activity of PLP-dependent enzymes and disrupt cellular metabolism, whereas excessive accumulation of free PLP could also cause metabolic imbalance. YggS-family proteins were widely conserved PLP homeostasis factors, yet how their expression was regulated had remained largely unknown. Here, we identified PhpR as a previously uncharacterized MocR-family transcriptional regulator that directly repressed the expression of YggS in
Indexed as
Alcaligenes faecalisBacterial ProteinsGene Expression Regulation, BacterialPyridoxal PhosphateTranscription FactorsPromoter Regions, GeneticBacterial ProteinsPyridoxal PhosphateTranscription FactorsAlcaligenesMocR-family regulator PhpRpyridoxal 5′-phosphateYggS
Identifiers
PMID42803569
PMCPMC13689441
What OpenQuestion holds
Textmetadata
Read underepoch 390