Evidence map›Paper›PMID 42803301›Full record

Observational studyAntiviral therapy2026

Kidney function parameters in South African children living with HIV on antiretroviral therapy.

Yanhan Shen, Elliott Y Huang, Olivia Yin, Stephanie Shiau, Renate Strehlau, Faeezah Patel, Louise Kuhn, Fangming Lin, Stephen M Arpadi

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antiviral therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanhan ShenVagelos College of Physicians and Surgeons, Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-9703-4412
Elliott Y HuangDepartment of Pediatrics, Division of Pediatric Nephrology, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Olivia YinVagelos College of Physicians and Surgeons, Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA.
Stephanie ShiauVagelos College of Physicians and Surgeons, Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA.
Renate StrehlauWits VIDA Nkanyezi Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Faeezah PatelWits RHI, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Louise KuhnVagelos College of Physicians and Surgeons, Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA.
Fangming LinDepartment of Pediatrics, Division of Pediatric Nephrology, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Stephen M ArpadiVagelos College of Physicians and Surgeons, Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-9129-2912

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Bone health in perinatally HIV-infected South African children on antiretroviralsR01HD073977 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARPADI, STEPHEN M, YIN, MICHAEL T · 2012 to 2016
$3.6M
NCATS NIH HHS UL1 TR001873NICHD NIH HHS R01 HD073977
6 · The paper itself

Abstract

BackgroundWe evaluated longitudinal kidney function in children with perinatally acquired HIV (CWH) compared with HIV-negative controls.MethodsWe analyzed data from an observational study in Johannesburg, South Africa (2013-2018), including 220 CWH on non-tenofovir regimens and 220 controls. Baseline and follow-up visits with blood, urine, and dual-energy X-ray absorptiometry (DXA) were conducted a median of 3.7 years apart. Kidney function was assessed using serum creatinine-based (revised bedside Schwartz equation) and cystatin C-based (univariate CKiD cystatin C equation) estimated glomerular filtration rates (eGFR) and urinary microalbuminuria, proteinuria, and

Indexed as

Anti-HIV AgentsHIV InfectionsKidneyAlbuminuriaChildChild, PreschoolCreatinineCystatin CFemaleGlomerular Filtration RateHumansKidney Function TestsLongitudinal StudiesMaleProteinuriaSouth AfricaAnti-HIV AgentsCreatinineCystatin Cchildren with perinatally acquired HIVchronic kidney diseaseestimated glomerular filtration ratekidney functionmicroalbuminuriaproteinuria

Identifiers

PMID42803301
PMCPMC13693377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.