Evidence map›Paper›PMID 42803268›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Identification of Crocin I as a positive modulator of GSTP1 with potential relevance to prostate cancer.

Hao Qin, YuanYuan Wang, Yukai Yang, Haihong Fang, Yangbiao Li, Yuxiu Yang, Yinhua Xiong, Lin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hao QinSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.
YuanYuan WangSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.
Yukai YangSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.
Haihong FangSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.
Yangbiao LiSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.
Yuxiu YangSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.
Yinhua XiongSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.
Lin ZhangSchool of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutathione S-transferase Pi 1 (GSTP1) is frequently silenced in prostate adenocarcinoma (PRAD), yet whether its residual catalytic activity can be chemically enhanced is largely unexplored. Here, we identify Crocin I as a positive modulator of GSTP1 through structure-based screening, biophysical characterisation, and biochemical validation. Bio-layer interferometry (BLI) supported a concentration-dependent association between Crocin I and GSTP1, and enzymatic assays demonstrated enhanced catalytic activity. Michaelis-Menten kinetics showed that Crocin I increased

Indexed as

CarotenoidsEnzyme InhibitorsGlutathione S-Transferase piProstatic NeoplasmsDose-Response Relationship, DrugHumansMaleMolecular StructureStructure-Activity RelationshipCarotenoidscrocinEnzyme InhibitorsGlutathione S-Transferase piGSTP1 protein, humanCrocin Ienzyme activityGSTP1prostate adenocarcinomavirtual screening

Identifiers

PMID42803268
PMCPMC13629784

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.