ArticleArchiv der Pharmazie2026
Spirooxindole 5-(Trifluoromethyl)benzothiazole Hybrids: Synthesis, Crystal Structure, and Antioxidant Activity.
Article in Archiv der Pharmazie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antioxidants neutralize free radicals to reduce oxidative stress and cellular damage, preventing various chronic diseases. In this study, the antioxidant activities of novel 5-(trifluoromethyl)-3H-spiro[1,3-benzothiazole-2,3'-indol]-2'(1'H)-ones (4a-h), along with the spirocyclic 2-indolinones (4i-m and 5a-n) previously synthesized by our group, were investigated for the first time, to find a multi-modal antioxidant and to understand the impact of the trifluoromethyl group located at the 5-position of the benzothiazole on antioxidant activity. For this purpose, the 2,2-diphenyl-1-picrylhydrazyl (DPPH•) free radical scavenging, superoxide anion scavenging, ABTS
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