ArticleEuropean journal of pain (London, England)2026
De Novo Pain in Pregnancy: The Mediating Roles of Depression and Maternal-Fetal Attachment in De Novo Chronic Pain.
Article in European journal of pain (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic pain affects up to 30% of pregnant individuals globally and substantially impairs maternal well-being. The prevalence and contributing factors of de novo chronic pain in pregnancy (DNPAP) remain poorly studied, with previous chronic pain rarely distinguished from newly arising pain. We examined the prevalence and characteristics of DNPAP and its association with foetal and maternal factors, including dysmenorrhea, depressive symptoms and maternal-foetal attachment.
methodsThis cross-sectional study included 207 pregnant women between 30 and 34 weeks of gestation. Assessments comprised pain measures (Douleur Neuropathique-4, McGill Pain Questionnaire, Brief Pain Inventory and Pain Catastrophizing Scale) and maternal well-being measures (Edinburgh Postnatal Depression Scale, Maternal-Foetal Attachment Scale and Prenatal Psychosocial Profile). Women with DNPAP were compared with those without chronic pain to identify associated factors.
resultsDe novo pain was reported by 20.7% of participants, with 59.6% describing it as moderate to severe. DNPAP was significantly associated with higher depressive symptoms, lower maternal-foetal attachment and a history of dysmenorrhea. Mediation analyses identified depressive symptoms as a key factor linking foetal malformations and gestational diseases to de novo pain.
conclusionDepression, reduced maternal-foetal attachment and a history of dysmenorrhea were significantly associated with de novo pain during pregnancy. Depressive symptom severity mediated the relationship between foetal malformations or gestational diseases and DNPAP. Clear characterization of pregnancy-related pain can inform preventive and therapeutic strategies to improve maternal health outcomes. SIGNIFICANCE STATEMENT: This study is the first to report the prevalence of de novo chronic pain during pregnancy, which was found to be high affecting 20.7% of the pregnant women. De novo chronic pain in pregnancy is directly associated with depressive symptoms and is mediated by depressive symptoms in cases involving foetal malformation diagnosis and the presence of gestational diseases. A history of dysmenorrhea is significantly associated with the development of de novo chronic pain in pregnancy, suggesting potential shared underlying mechanisms that open possibilities for testing new early-detection, therapeutic, and prognostication approaches to pain across women's life-cycle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.