Trial reportDrug design, development and therapy2026
Effective Dose 90 of Programmed Intermittent Epidural Bolus Volume at Three Ropivacaine Concentrations with Dural Puncture Epidural for Labor Analgesia: A Randomized Sequential Allocation Study.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Interpreting ED90 Estimates in a Sequential Labor Analgesia Study [Letter].Drug design, development and therapy · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aimed to explore the ED90 of programmed intermittent epidural bolus (PIEB) volume for labor analgesia with different concentrations of ropivacaine when combining with dural puncture epidural (DPE) techniques. Methods: Ninety patients were randomized to three groups (n=30 each) to receive an initial 12-mL bolus of ropivacaine (0.075%, 0.1%, or 0.125%) with 0.3 μg/mL sufentanil. PIEB began at 60 min after the initial bolus, with 45-min intervals; the first patient in each group received 10 mL ropivacaine‑sufentanil solution, and subsequent volumes were adjusted by ± 2 mL via sequential allocation based on effective labor analgesia (no epidural bolus intervention administered). The primary and secondary outcomes were, respectively, the ED90 of PIEB volume at different ropivacaine concentrations for effective labor analgesia, and maternal analgesia quality and neonatal outcomes. Results: The ED90 of PIEB volume for achieving effective labor analgesia was 13.2 mL (95% CI, 11.9-14.5), 11.1 mL (95% CI, 10.0-12.2), and 9.4 mL (95% CI, 8.4-10.3) in the 0.075%, 0.1%, and 0.125% groups, respectively. No statistically significant differences in maternal analgesia quality and neonatal outcomes were identified among groups. Conclusion: When the combined DPE and PIEB technique is applied for effective labor analgesia, the ED90 of PIEB volume at concentrations of 0.075%, 0.1%, and 0.125% is 13.2 mL, 11.1 mL, and 9.4 mL respectively. Since higher concentration corresponds to a higher administered dose of ropivacaine, the ED90 of PIEB volume decreases as concentration increases.
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