Evidence map›Paper›PMID 42802645›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

GABA

Zsolt Cselényi, Aurelija Jucaite, Lars Farde

2 registry-linked trialsAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00681720 phase1completednot on this map

An Open Label Positron Emission Tomography (PET) Study With (11C)Flumazenil to Determine Central GABAA Receptor Occupancy of AZD7325 After Oral Administration to Healthy Volunteers

TypeinterventionalSponsorAstraZenecaRan2008 to 2008Enrolled4ConditionsAnxietyArmsAZD7325, Radioligand (11C) flumazenil
NCT00681746 phase1completednot on this map

An Open Label Positron Emission Tomography (PET) Study With (11C)Flumazenil to Determine Central GABAA Receptor Occupancy of AZD6280 After Oral Administration to Healthy Volunteers

TypeinterventionalSponsorAstraZenecaRan2008 to 2008Enrolled8ConditionsAnxietyArmsAZD6280, (11C) flumazenil
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zsolt CselényiPET Science Center, R&D, AstraZeneca, Stockholm, Sweden.ORCID 0000-0002-8479-6282
Aurelija JucaitePET Science Center, R&D, AstraZeneca, Stockholm, Sweden.ORCID 0000-0002-2281-6436
Lars FardePET Center, Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1297-0816

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

backgroundWe recently published putative in vivo maps of GABA

methodsCortical α subunit maps were projected to the symmetric fs_LR template and compared with the Human Connectome Project multi‑modal parcellation. Congruence was assessed by visual inspection, within‑parcel variability, and the distance‑controlled boundary coefficient (DCBC) with spin‑permutation null models. Subunit profiles were summarized per cortical area and related to functional networks.

resultsInspection revealed conspicuous congruence between α -subunit distributions and areal boundaries. α

conclusionCortical GABA CLINICALTRIALS: gov: NCT00681720 and NCT00681746.

Indexed as

[11C]flumazenil positron emission tomographychemiarchitectonicsGABAA receptor α subunit mapslarge-scale functional brain networksmultimodal cortical parcellation

Identifiers

PMID42802645
PMCPMC13675412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.