ArticleJournal of bone and mineral metabolism2026
Performance of screening tools for osteoporosis and fractures in community-dwelling elderly Japanese men.
Article in Journal of bone and mineral metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe Osteoporosis Self-Assessment Tool for Asians (OSTA) was originally developed for postmenopausal Asian women, but its performance in men is inadequately characterized. This study evaluated the diagnostic accuracy of OSTA for identifying osteoporosis and predicting major osteoporotic fractures (MOF) in elderly Japanese men, and compared its fracture prediction capability with the fracture risk assessment tool (FRAX MATERIALS AND
methodsData were drawn from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) cohort. The primary analysis included 1888 men aged 65-94 years. Osteoporosis was defined by dual-energy X-ray absorptiometry (DXA)-derived T-score ≤-2.5 at the lumbar spine, total hip, or femoral neck. OSTA and FRAX
resultsThe area under the curve (AUC) of OSTA for identifying osteoporosis was 0.777 (95% CI 0.714-0.840) in men aged 65-74 years and 0.739 (95% CI 0.666-0.812) in those aged ≥75 years. Optimal OSTA cutoff values (- 3 and -5, respectively) differed substantially from the conventional female-derived threshold of ≤-1. For MOF prediction, the AUC of OSTA was not significantly different from that of FRAX
conclusionOSTA demonstrated moderate discriminative ability for DXA-defined osteoporosis in elderly Japanese men; however, age-specific cutoff values are required. The comparable fracture prediction performance of OSTA and FRAX
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