Evidence map›Paper›PMID 42802198›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2026

Electroretinographic assessment of retinal function in preterm infants using the RETeval™ device: a proposal for reference data.

Viviane Lanzelotte, Eduardo F Damasceno, Bárbara Gonet, Carolina do Val F Ramos, Christina Gerth-Kahlert, James V M Hanson, José Eduardo da Silva, Saint Clair Gomes Junior, Arnaldo Costa Bueno, Tatiana Guimarães de Noronha

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Article in Documenta ophthalmologica. Advances in ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Viviane LanzelotteGraduate Program in Medical Sciences, Fluminense Federal University (UFF), Rua Miguel de Frias, 9, Icaraí, Rio De Janeiro, Niterói, CEP, 24220-900, Brazil. vlanzelotte@gmail.com.
Eduardo F DamascenoDepartment of Ophthalmology, School of Medicine, Fluminense Federal University, Niterói, Brazil.
Bárbara GonetRio de Janeiro Municipal Health Department, Rio de Janeiro, Brazil.
Carolina do Val F RamosPrivate Practice, Rio de Janeiro, Brazil.
Christina Gerth-KahlertDepartment of Ophthalmology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
James V M HansonDepartment of Ophthalmology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
José Eduardo da SilvaRio de Janeiro Municipal Health Department, Rio de Janeiro, Brazil.
Saint Clair Gomes JuniorClinical Research Unit, Fernandes Figueira Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
Arnaldo Costa BuenoDepartment of Maternal and Child Health, School of Medicine, Fluminense Federal University, Niterói, Brazil.
Tatiana Guimarães de NoronhaDepartment of Maternal and Child Health, School of Medicine, Fluminense Federal University, Niterói, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo establish age-adjusted flicker ERG reference values in premature infants through serial recordings, aiming to characterize retinal functional maturation and support diagnostic interpretation in retinopathy of prematurity screening.

methodsThis prospective longitudinal study was conducted between April 2022 and October 2023 across six public neonatal care centers in Rio de Janeiro, Brazil. Premature infants eligible for ROP screening (birth weight ≤1500 g and/or gestational age ≤32 weeks) underwent serial retinal examinations with binocular indirect ophthalmoscopy and flicker electroretinography. Examinations were discontinued at ROP treatment indication or at 42 weeks postmenstrual age. Flicker ERG recordings were performed using a hand-held RETeval® device equipped with small-sized Sensor Strip™ skin electrodes. A 30 cd·s/m

resultsOf the 199 premature infants, 94 (171 eyes) who never progressed beyond stage 0 ROP were included in the reference analysis. Serial ERG recordings demonstrated a consistent decrease in implicit time and increase in amplitude with advancing PMA. At 32-34 weeks PMA, the upper reference limits (97.5th percentile) were 44.8 ms and 8.5 µV, respectively, compared with 43.5 ms and 24.9 µV at 40-42 weeks PMA.

conclusionAge-adjusted ERG reference values derived from serial recordings characterize retinal functional maturation in preterm infants, providing a framework for ERG interpretation during routine ROP screening and future studies of retinal development.

Indexed as

Blindness preventionElectrorretinogramOphthalmologyPortable ERG deviceReference dataRetinopathy of prematurity

Identifiers

PMID42802198

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