In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Anusha RengarajanDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Sicong WangDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Chien-Wei LinDivision of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0003-4023-7339 Lauren E ElberfeldDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0009-0000-4289-4960 Jenna C WettsteinDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Amber E CarletonDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0002-7347-6945 Nikola SekulovskiDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0003-3451-7262 Linnea E TaniguchiDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Bailey E SchultzDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Mara C DuncanDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA. mcduncan@med.umich.edu.ORCID 0000-0002-2383-0109 Kenichiro TaniguchiDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA. ktaniguchi@mcw.edu.ORCID 0000-0002-4531-7197 Funding
Molecular regulators of human amniogenesisR01HD098231 · NICHD · MEDICAL COLLEGE OF WISCONSIN · PI Kenichiro Taniguchi · 2019 to 2026
$3.3MMechanism of apicosome-driven lumen formation during human and mouse embryogenesisR01HD102496 · NICHD · MEDICAL COLLEGE OF WISCONSIN · PI TANIGUCHI, KENICHIRO · 2020 to 2024
$1.9MCharacterizing new proteins that determine AP-1 recruitment and distributionR01GM129255 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUNCAN, MARA C · 2019 to 2022
$1.2MNICHD NIH HHS R01 HD098231NICHD NIH HHS R01 HD102496NIGMS NIH HHS R01 GM129255U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01-HD098231U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01-HD102496U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01-GM129255
6 · The paper itselfAbstract
Epiblast lumen formation is a critical step that occurs during human embryo implantation. It begins with the apicosome, an apical compartment partly derived from endocytosed material. However, how the endo-lysosomal system contributes to apicosome formation and later lumen development remains unclear. Using a human pluripotent stem cell-derived model of epiblast formation, we show that apicosome formation is accompanied by transient expansion of early endosomes, late endosomes, and lysosomes, as well as the formation of hybrid compartments with features of both early and late endo-lysosomal stages. These changes depend on the RAB GTPases RAB35 and RAB7, which are required for proper apicosome formation and lumen morphology of the human epiblast model. Our findings identify RAB35- and RAB7-dependent endo-lysosomal remodeling as a key mechanism driving apical membrane morphogenesis during human epiblast development.
Indexed as
EndosomesGerm LayersLysosomesHumansPluripotent Stem Cellsrab7 GTP-Binding Proteinsrab GTP-Binding Proteinsrab7 GTP-Binding Proteinsrab7 GTP-binding proteins, humanrab GTP-Binding Proteins
Identifiers
PMID42802159
PMCPMC13616919
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