Evidence map›Paper›PMID 42801764›Full record

ArticleChemistry & biodiversity2026

Design, Synthesis, In Silico Studies, and HIV-1 RT Inhibitory Activity of 1,3-Oxazolidine Pyrimidine Nucleoside Analogues.

Shimoga Nagaraj Sriharsha, Zaid Mahmood Mohamed, Ammar A Razzak Mahmood, Sibghatullah Muhammad Ali Sangi, Sadik Shaik, Sreeharsha Nagaraja, Sheeba Kumari, Vidhya Thirunavukkarasu, Pavan Kumar Sreenivasalu, Monirul Islam and 2 more

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shimoga Nagaraj SriharshaDepartment of Pharmaceutical Chemistry, National College of Pharmacy, Shimoga, India.
Zaid Mahmood MohamedDepartment of Pharmaceutical Chemistry, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq.ORCID https://orcid.org/0009-0004-4445-954X
Ammar A Razzak MahmoodDepartment of Pharmacy, Al Ma'moon University, 14-Ramadan Street, Baghdad, Iraq.ORCID https://orcid.org/0000-0002-4915-417X
Sibghatullah Muhammad Ali SangiBasic Medical Sciences Department, Dar Al Uloom University, Riyadh, Saudi Arabia.
Sadik ShaikDepartment of Pharmacology, Anuradha College of Pharmacy, Bengaluru, India.ORCID https://orcid.org/0000-0003-0176-3504
Sreeharsha NagarajaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.ORCID https://orcid.org/0000-0002-2058-255X
Sheeba KumariDepartment of Nursing College of Applied Medical Sciences, King Faisal University, Al-Ahsa, Saudi Arabia.
Vidhya ThirunavukkarasuDepartment of Nursing College of Applied Medical Sciences, King Faisal University, Al-Ahsa, Saudi Arabia.ORCID https://orcid.org/0000-0002-7006-3694
Pavan Kumar SreenivasaluDepartment of Restorative Dentistry and Endodontics, College of Dentistry, King Faisal University, Al-Ahsa, Saudi Arabia.
Monirul IslamDepartment of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.ORCID https://orcid.org/0000-0001-8010-4712
Muhammad Shahzad ChohanDepartment of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
Mahalakshmi Suresha BiradarDepartment of Pharmaceutical Chemistry, National College of Pharmacy, Shimoga, India.ORCID https://orcid.org/0000-0002-3928-2338

Funding

Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia KFU264639
6 · The paper itself

Abstract

A series of 1,3-oxazolidine nucleoside analogues (1-6) was designed and synthesized for their anti-HIV activity. The purpose of this study was to determine whether the antiviral activity of the pyrimidine ring is affected by oxazolidine ring substitution. The synthesized compounds were tested for their HIV-1 RT inhibitory activity by a colorimetric HIV reverse transcriptase (HIVRT) test. The fluoro (S4) and bromo (S5) derivatives of these compounds showed the highest HIV-1 reverse transcriptase IC

Indexed as

Anti-HIV AgentsDrug DesignHIV-1HIV Reverse TranscriptaseOxazolesPyrimidine NucleosidesReverse Transcriptase InhibitorsDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAnti-HIV AgentsHIV Reverse TranscriptaseOxazolesoxazolidinePyrimidine Nucleosidesreverse transcriptase, Human immunodeficiency virus 1Reverse Transcriptase Inhibitors1,3‐oxazolidineanti‐HIVdockingnucleosidesynthesis

Identifiers

PMID42801764
PMCPMC13616464

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.