ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hyperactivated M1 macrophages with excessive reactive oxygen species (ROS) exacerbate intestinal inflammation, driving the progression of inflammatory bowel diseases (IBDs), for instance, ulcerative colitis. Current standard treatments for IBDs show limited efficacy and off-target side effects. Herein, we develop an oral, drug-free hyaluronic acid (HA)-based therapeutics that could self-assemble in aqueous solution, accumulate in inflamed colons and attenuate M1-like activation, thereby rebalancing the colonic immune landscape. Such drug-free therapeutics are generated by the conjugation of unsaturated fatty acids to HA via dynamic covalent boronate-catechol ester bonds. Mechanistically, the nano-assemblies (termed uhNAs) effectively scavenge ROS, dampen NF-κB signaling, and diminish pro-inflammatory cytokines in M1-like phenotypes. In DSS-induced acute colitis, oral uhNAs treatment elicits significant decreases in M1-like macrophages, CD8
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