Evidence map›Paper›PMID 42801687›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

High-Density Type I Collagen Promotes IFN-γ

Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jinyan Wang *Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Shuangyue Pan *Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Lu BaiDepartment of Ultrasonography, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID https://orcid.org/0009-0002-9990-8010
Bin LiDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Tiantian LiuDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Jianing CaoDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Mengdi YangDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID https://orcid.org/0000-0002-5474-6890
Heda ZhangDepartment of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Jiangsu, China.ORCID https://orcid.org/0000-0001-6599-2782
Duancheng GuoDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID https://orcid.org/0000-0002-5915-7390
Wenxiang ZhiDepartment of Ultrasonography, Fudan University Shanghai Cancer Center, Shanghai, China.
Zhonghua TaoDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Xichun HuDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID https://orcid.org/0000-0001-6148-9186

Funding

National Natural Science Foundation of China 82103032National Natural Science Foundation of China 82473071Natural Science Foundation of Shanghai 23ZR1412400Program for Shanghai Outstanding Academic Leader LJRC2102Program for Shanghai Outstanding Academic Leader LJRC2102-PShanghai Anticancer Association SOAR PROJECT SACA-AX202106Shanghai Municipal Health Commission Clinical Research Special Project for the Health Industry 20264Y0081
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by poor prognosis because of a lack of effective therapeutic agents. Changes in extracellular matrix (ECM) composition, particularly type I collagen density, significantly influence crucial cellular activities. However, the association between type I collagen density and TNBC progression remains unclear. This study finds that type I collagen density and mechanical characteristics of lesions predict the pathological grade and malignant progression of TNBC patients. The results of transcriptomics and metabolomics studies suggest that high-density type I collagen promotes TNBC ferroptosis. Further in vitro experiments indicate that high-density type I collagen promotes ferroptosis in TNBC cells through spermidine/spermine N1-acetyltransferase 1 (SAT1)/argininosuccinate synthase (ASS1)-induced glutamine (Gln) accumulation. Moreover, in vitro co-culture and in vivo experiments reveal that high-density type I collagen increases the uptake of Gln in TNBC cells, leading to Gln deprivation of IFN-γ

Indexed as

ferroptosisglutamineSAT1TNBCType I collagen density

Identifiers

PMID42801687
PMCPMC13616355

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.