Evidence map›Paper›PMID 42801682›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions.

Joshua Y Liu, Ziqian Yang, Arina E Velieva, Eleanor M Plaster, Mingyue Fan, Donia W Ahmed, Avinava Roy, Pamela Duran, Pamela Panovich, Alexandra S Piotrowski-Daspit and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Joshua Y LiuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.ORCID https://orcid.org/0000-0003-4874-7149
Ziqian YangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.ORCID https://orcid.org/0009-0005-6648-2713
Arina E VelievaDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.ORCID https://orcid.org/0000-0002-2825-6919
Eleanor M PlasterDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.ORCID https://orcid.org/0009-0005-2965-1485
Mingyue FanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.ORCID https://orcid.org/0000-0002-8365-7571
Donia W AhmedDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.ORCID https://orcid.org/0000-0003-4243-5427
Avinava RoyCenter for Precision Engineering for Health (CPE4H), University of Pennsylvania, Philadelphia, USA.ORCID https://orcid.org/0000-0002-1411-5189
Pamela DuranDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.
Pamela PanovichDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.ORCID https://orcid.org/0009-0001-9623-1254
Alexandra S Piotrowski-DaspitDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.ORCID https://orcid.org/0000-0003-4555-3234
Carlos A AguilarDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.ORCID https://orcid.org/0000-0003-3830-0634
Megan L KillianDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.ORCID https://orcid.org/0000-0001-6868-5550
Claudia LoebelDepartment of Bioengineering, University of Pennsylvania, Philadelphia, USA.ORCID https://orcid.org/0000-0002-3140-5663

Funding

Regulation of Tendon Enthesis Development and Healing via HIF1R01AR082348 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Megan L. Killian · 2024 to 2026
$1.6M
Implementing the nascent ECM into the dynamic reciprocity of cell-ECM interactionsR35GM157063 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Claudia Loebel · 2025 to 2026
$813k
Engineered alveolar organoids to understand ECM signalingR00HL151670 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOEBEL, CLAUDIA · 2021 to 2023
$747k
Engineered alveolar organoids to understand ECM signalingK99HL151670 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LOEBEL, CLAUDIA · 2020 to 2020
$124k
NHLBI NIH HHS K99 HL151670NHLBI NIH HHS R00 HL151670NHLBI NIH HHS R00-HL151670NIAMS NIH HHS R01 AR082348NIGMS NIH HHS R35 GM157063NIGMS NIH HHS R35GM157063NIH R01AR082348
6 · The paper itself

Abstract

Hydrogels serve as powerful models for investigating cell-extracellular matrix (ECM) interactions. While chemical modifications are routinely used to tune hydrogel properties, it remains unclear whether these modifications mediate cell fate. Previous work has shown that cells deposit newly synthesized (nascent) ECM at the cell-hydrogel interface. Here, we demonstrate that this nascent ECM interface regulates how cells interpret chemical modifications. Using hydrogels with varied chemical modifications, we isolated the effects of chemical modification on nascent ECM and cell fate. Nascent ECM deposition increased as a function of hydrogel modification and with distinct matrisome compositions. While low-modification hydrogels promoted cell differentiation, high modifications increased cell proliferation. Perturbing cell- nascent ECM interactions reversed this cell fate. Our findings reveal that nascent ECM regulates cell fate by converting hydrogel cues into signals that control cell fate. This tri-directional interplay among hydrogel chemical modifications, nascent ECM, and cell fate reframes how we interpret cell-hydrogel interactions.

Indexed as

biomaterialcell biologycell fate determinationcell growthcellular differentiationchemistryextracellular matrix

Identifiers

PMID42801682
PMCPMC13616248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.