Evidence map›Paper›PMID 42801663›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Bio-Memristor Based on Clinical Bile Samples: A Proof-of-Concept Pilot Study for Detection of Gallbladder Cancer.

Junming Zhu, Yiyin Rong, Bai Sun, Ziwen Sun, Yifan Wang, Xiaobin Ren, Zelin Cao, Kaikai Gao, Jiawei Yu, Zhenkun Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Junming Zhu *Department of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0009-0009-5217-5957
Yiyin Rong *Department of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0009-0001-6647-5143
Bai SunDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0002-5840-509X
Ziwen SunDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yifan WangDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiaobin RenFrontier Institute of Science and Technology, and Interdisciplinary Research Center of Frontier Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zelin CaoFrontier Institute of Science and Technology, and Interdisciplinary Research Center of Frontier Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Kaikai GaoFrontier Institute of Science and Technology, and Interdisciplinary Research Center of Frontier Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jiawei YuDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0001-8730-1452
Zhenkun WangDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0009-0005-4837-7688
Haoxuan MaDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jichun GuoDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Kai CaoDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Mengrun KangDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Songling WangState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China.ORCID https://orcid.org/0000-0003-4226-6870
Fenggang RenNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0002-9239-9279
Yi LvNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Qiang LuDepartment of Abdominal Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0002-8294-4966

Funding

Basic Research Project of Xi'an Jiaotong University xtr052025010Basic Research Project of Xi'an Jiaotong University xtr062025002Basic Research Project of Xi'an Jiaotong University xtr072024022National Natural Science Foundation of China 52375575School Recruitment Joint Special Project of Shaanxi SXXZGY202401Science and Technology Plan Project of Shaanxi 2025JC-TBZC-05
6 · The paper itself

Abstract

Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system, and the 5-year survival rate of GBC patients is only 5% due to delayed diagnosis. The sensitivity and specificity of existing clinical testing equipment for gallbladder malignancy remain insufficient. In this proof-of-concept pilot study, we developed a bio-memristor featuring an Ag/bile/fluorine-doped tin oxide structure using clinically sourced bile samples from a small clinical cohort and characterized its resistive switching behavior. The memristive electrical signatures, particularly negative peak current and the high-resistance-state to low-resistance-state ratio, differed systematically across people with normal gallbladder, cholelithiasis patients, and GBC patients, enabling a two-step detection strategy. Within this pilot cohort, the detection performance was encouraging. These findings establish the technical feasibility of memristor-based bile detection for gallbladder cancer and provide a foundation for developing detection technology that is expected to complement existing clinical approaches to improve gallbladder cancer identification.

Indexed as

bio‐electronic interfaceintelligent medicinemedical detectionmemristive signaturememristor

Identifiers

PMID42801663
PMCPMC13616236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.