Evidence map›Paper›PMID 42801617›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Developing Metal-Polyphenol Network-Based Single-Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia.

Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yafei ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0003-2130-847X
Yuning ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0006-5636-8770
Yongjian AiMOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Yao LuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-8426-477X
Heng QuanMOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Zhen ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Yuqi WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Yujia LuoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Xiaoxu ZhangMOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0003-0361-5556
Yingying LinMOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0006-4404-8390
Sijia SongMOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0001-5633-3275
Huiyuan GuoMOE Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0003-0792-177X

Funding

Beijing Outstanding Young Scientist Program JWZQ2024101019National Key Research and Development Program of China 2023YFF1104505
6 · The paper itself

Abstract

Sarcopenia has emerged as a major health challenge in the aging population. Whey protein (WP)-rich in branched-chain amino acids-is an important nutritional supplement for mitigating sarcopenia. However, the rapid digestion of WP limits its therapeutic efficacy. Developing a sustained-release system for WP may enhance its effectiveness in mitigating sarcopenia. Herein, a novel "single-protein particle encapsulation" (SPPE) system is developed to protect WP and control its release. Specifically, the "molecular glue" metal-polyphenol networks (MPNs) are assembled onto the surface of individual polymerized WP isolate (PWPI) particles as an intermediate layer and bridged with the saccharide hyaluronic acid (HA) to construct PWPI@MPNs/HA. The results showed that PWPI@MPNs/HA precisely regulates the release rate of PWPI in the gastrointestinal tract. In a murine sarcopenia model, PWPI@MPNs25/HA significantly improves lean body content, grip strength, grid hanging time, exhaustion time, and exhaustion distance. The underlying molecular mechanism involves activation of the PI3K/AKT/mTOR signaling pathway and suppression of the muscle atrophy factors MuRF-1 and Atrogin-1 in the ubiquitin-proteasome system via PWPI@MPNs/HA. The SPPE system developed in this study may have broad future applications in protein protection and delivery.

Indexed as

metal polyphenol networksmuscular atrophysaccharidesarcopeniaself‐assemblysingle‐protein particle encapsulation systemwhey protein

Identifiers

PMID42801617
PMCPMC13616254

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.