Evidence map›Paper›PMID 42801615›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G-Quadruplex-Mediated Activation of the Pla2g4a-Prostaglandin Axis.

Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xinyue Lan *Food Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.
Qiu Dai *Key Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, People's Republic of China.ORCID https://orcid.org/0009-0005-7589-4517
Yanhui Wang *Food Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.
Jiaxuan GuFood Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.
Chengyun WangFood Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.
Weicheng XuFood Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.
Xinru GaoFood Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.
Jiageng ChengFood Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.
Wentao GengFood Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.
Xiaowen WuJiangsu Trautec Medical Technology Co., Ltd, Jiangsu, People's Republic of China.
Haihang LiJiangsu Trautec Medical Technology Co., Ltd, Jiangsu, People's Republic of China.
Xiaoyun HeKey Laboratory of Precision Nutrition and Food Quality, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0002-9503-8532
Shengwei FuJiangsu Trautec Medical Technology Co., Ltd, Jiangsu, People's Republic of China.
Longjiao ZhuFood Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0002-5051-6406
Wentao XuFood Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0002-8572-8257

Funding

Beijing Nova Program 20230484463Internal Horizontal Service Contract of China Agricultural University entitled Study on Repair Test of Collagen for Gastric Mucosal Injury 202305523140776
6 · The paper itself

Abstract

Ethanol-induced acute gastric mucosal injury (AGMI) remains a prevalent clinical problem, while current therapies are constrained by adverse effects and the immunogenicity of animal-derived collagens. Here, we evaluate orally administered recombinant human type III collagen (RC) as a gastroprotective biomaterial. Following oral administration, RC reduced gastric mucosal lesion area by 78% within the dynamic acidic gastric environment, provided approximately 1.5-fold greater protection than commercial animal-derived collagens, and exhibited excellent biosafety. Integrated metabolomic and transcriptomic analyses revealed coordinated regulation of glutathione-centered redox homeostasis, cytoskeletal and tight-junction barrier repair, and metabolic-inflammatory networks. Targeted LC-MS/MS confirmed the transient occurrence of the RC-derived pentapeptide GPAEF in gastric mucosal lavage 30 min after administration. GPAEF selectively recognized and stabilized the Pla2g4a promoter G-quadruplex (G4), exhibiting approximately 13-fold higher affinity than ThT and enhancing G4 folding under physiologically relevant ionic conditions. Molecular dynamics simulations indicated that GPAEF shifted the Pla2g4a G4 from a preferentially parallel topology toward hybrid/mixed conformations and stabilized the peptide-G4 complex, providing a dynamic basis for Pla2g4a transcription and downstream prostaglandin biosynthesis. These findings establish RC as a safe and effective biomaterial for ethanol-associated gastropathy and identify G4-mediated activation of the Pla2g4a-prostaglandin axis as a key pathway contributing to its gastroprotective effects.

Indexed as

Ethanol‐induced acute gastric mucosal injuryGastric mucosal protectionG‐quadruplexMetabolic reprogrammingPla2g4a‐prostaglandin axisRecombinant human collagen III

Identifiers

PMID42801615
PMCPMC13616389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.