Evidence map›Paper›PMID 42801583›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Hierarchical Nanoplatform Integrating Oxidative-Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy.

Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xu Chen *Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0008-3928-1598
Xingyu Zhu *Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Zhixin QiuChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Yijia ZhuChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Xinhui ZhengChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0005-6551-1201
Dongqi FanChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Jinglei ZhanChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Congxiu MaoChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.
Ping JiThe Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-2608-1035
Tao ChenChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-5658-5525
Qingqing HeChongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China.

Funding

China Postdoctoral Science Foundation 2024M763903Chongqing Municipal Graduate Scientific Research Innovation Project CYB25230Chongqing Municipal Graduate Scientific Research Innovation Project CYS240318Graduate Scientific Research Innovation Project, College of Stomatology, Chongqing Medical University KQY202402Graduate Scientific Research Innovation Project, College of Stomatology, Chongqing Medical University KQY202513Joint Funds of the National Natural Science Foundation of China U25A2099National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 32322044Special Funding Program for Postdoctoral Research Projects of Chongqing 2025CQBSHTB2018
6 · The paper itself

Abstract

Diabetic craniofacial bone defects exhibit unsatisfactory repair attributed to synergistic oxidative stress, local acidification and disordered bone immunity, whereas conventional mono-functional biomaterials are incapable of synchronously resolving these interlocked pathological cascades. Herein, a hierarchical nanoplatform (CM/LDH) is fabricated by immobilizing Ce-MOF nanozyme onto CaAl-LDH substrate for synergistic bone remediation. As an alkaline and bioactive support, CaAl-LDH improves peri-defect microenvironment acidification to preserve the redox catalytic activity of loaded Ce-MOF, accompanied with sustained Ca

Indexed as

antioxidant nanozymediabetic bone defect repairmicroenvironment regulationmitochondrial homeostasisosteogenesis‐osteoclastogenesis balance

Identifiers

PMID42801583
PMCPMC13616312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.