ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
A Gut-Brain Axis Underlying Succinate-Associated Compulsive-Like Behavior.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Emerging evidence indicates that gut microbiota influences host physiology and behavior through the microbiota-gut-brain axis, potentially contributing to the pathogenesis of obsessive-compulsive disorder (OCD). Our preliminary research demonstrated that mice colonized with fecal microbiota from OCD patients developed compulsive-like behaviors, associated with a significant increase in the microbial metabolite succinate. However, the mechanisms linking succinate to compulsive-like behavior remain to be fully elucidated. Here, we demonstrate that succinate is associated with significant compulsive-like behaviors. Succinate is associated with disruptions of glutamatergic neurons within the dorsal medial prefrontal cortex (dmPFC), and we characterize dual pathways linked to the behavioral abnormality: both by dmPFC microglial engagement via the succinate cognate receptor SUCNR1, and by gut-to brain signaling conveyed through vagal afferents and the 5-HT
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