ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Temporal-Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye and 1 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
Rong Guo *Department of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.ORCID https://orcid.org/0000-0001-5038-0599 Xingxing Li *Department of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.ORCID https://orcid.org/0000-0003-3929-7625 Chenjun ZouDepartment of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.
Chao ZhengDepartment of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.ORCID https://orcid.org/0009-0008-5757-2452 Xiaohong WuDepartment of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.
Xuechao LuDepartment of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.
Jiaying YanDepartment of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.
Junfang ZhangSchool of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, People's Republic of China.
Xiaoyan LuoDepartment of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.
Shiwei YeDepartment of Psychiatry, The Second People's Hospital of Lishui, Lishui, Zhejiang, People's Republic of China.
Dongsheng ZhouDepartment of Psychiatry, Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo, Zhejiang, People's Republic of China.ORCID https://orcid.org/0009-0002-9326-4242 Funding
Lishui Municipal Public Welfare Technology Application Research Program No.2024GYX41Ningbo Clinical Medical Research Centre for Mental Health No.2022L002Ningbo Medical and Health Brand Discipline No.PPXK20182024-0708Ningbo Public Welfare Science and Technology Plan Project 2023S035Ningbo Top Medical and Health Research Program No.2022030410
6 · The paper itselfAbstract
The temporal lobes are key hubs for memory and cognition. Although 40 Hz transcranial alternating current stimulation (tACS) has shown potential cognitive benefits, evidence for accelerated bilateral temporal stimulation remains limited. This study aims to evaluate its cognitive and neural effects. In this randomized, double-blind, controlled trial, 100 Alzheimer's disease (AD) patients were randomized 1:1 to active or sham 40 Hz tACS over the bilateral temporal. Cognitive outcomes at three time points were analyzed using mixed repeated-measures analysis of variance (ANOVA). Resting-state functional near-infrared spectroscopy (fNIRS) data from baseline and Week 4 were analyzed using ANOVA, followed by network-based statistics with family-wise error (FWE) correction. Eighty-five participants completed the trial. Significant Group × Time interactions were observed for Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) total (p = 0.010), memory (p = 0.007), and praxis (p = 0.002), but not for the Mini-Mental State Examination (MMSE) (p = 0.075). The fNIRS analysis revealed a functional network primarily involving the frontal and parietal regions, comprising 38 connections and 18 nodes (p
Indexed as
40 Hz transcranial alternating current stimulationalzheimer's diseasecognitive functionfunctional connectivityfunctional near‐infrared spectroscopy
Identifiers
PMID42801558
PMCPMC13616376
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