Evidence map›Paper›PMID 42801530›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics.

Pengfei Zhang, Benjamin K Law, Niles Huang, Katharine Goodwin, Celeste M Nelson, Michelle M Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Pengfei Zhang *Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA.ORCID https://orcid.org/0000-0002-8578-8305
Benjamin K Law *Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Niles HuangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.ORCID https://orcid.org/0009-0001-7601-2011
Katharine GoodwinLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.ORCID https://orcid.org/0000-0002-4823-7491
Celeste M NelsonDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA.ORCID https://orcid.org/0000-0001-9973-8870
Michelle M ChanLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.ORCID https://orcid.org/0000-0001-9451-9716

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Mechanical Clocks During Fetal DevelopmentDP1HD111539 · NICHD · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2022 to 2025
$5.7M
Building a Systematic, Comprehensive Mammalian Cell Fate MapDP2HD111537 · NICHD · PRINCETON UNIVERSITY · PI CHAN, MICHELLE · 2022 to 2025
$2.2M
Interplay between mechanical forces and retinoic acid in lung developmentR01HL164861 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2022 to 2025
$2.2M
Mechanical Forces and the Regulation of Airway Progenitor CellsR01HD099030 · NICHD · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2019 to 2023
$1.7M
National Science Foundation 2134935NHLBI NIH HHS R01 HL164861NICHD NIH HHS DP1 HD111539NICHD NIH HHS DP2 HD111537NICHD NIH HHS R01 HD099030NIGMS NIH HHS T32 GM007388NIH HHS HD099030NIH HHS HD111537NIH HHS HD111539NIH HHS HD144311NIH HHS HL164861NIH HHS T32GM007388
6 · The paper itself

Abstract

The mature mammalian lung contains ∼50 different cell types that are located in precise positions along and around the airway epithelial tree. Here, we apply spatial transcriptomics to early embryonic mouse lungs to investigate how these spatial patterns are progressively established during development. Specifically, we optimized a microfluidics-enabled, deterministic barcoding-based sequencing (DBiT-seq) workflow to achieve sensitive spatial mapping of tissue sections, resulting in up to a twofold increase in average transcript recovery compared with previous implementations. Spatial mapping of epithelial populations revealed that Sox9

Indexed as

cell‐cell interactionmorphodynamicsmorphogenesispulmonary mesenchyme

Identifiers

PMID42801530
PMCPMC13616284

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.