Evidence map›Paper›PMID 42801357›Full record

ArticleMolecular biology reports2026

Genomic characterization of non-fermenting gram-negative bacilli with metallo beta lactamase production and mcr based colistin resistance causing soft tissue infections: a seven-year hospital based prospective cross-sectional study.

Ankan Chakrabarti, Tapan Majumdar, Sibabrata Bhattacharya

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Ankan ChakrabartiDepartment of Microbiology, AGMC & GBP Hospital, Agartala, Tripura, India. ankanagmc@gmail.com.ORCID http://orcid.org/0000-0003-2882-9606
Tapan MajumdarDepartment of Microbiology, AGMC & GBP Hospital, Agartala, Tripura, India.ORCID http://orcid.org/0000-0002-5375-133X
Sibabrata BhattacharyaDepartment of Microbiology, AGMC & GBP Hospital, Agartala, Tripura, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-fermenting Gram-negative bacilli (NFGNB) like Pseudomonas aeruginosa and Acinetobacter baumannii have emerged as major nosocomial pathogens, particularly causing tissue infections. Rising resistance to carbapenems and colistin, largely mediated by Metallo-β-lactamase (MBL) and mobile colistin resistance (mcr) genes respectively, has severely limited therapeutic options. This study aimed to determine the proportion of MBL and mcr genes in NFGNB strains causing soft tissue infections and analyze their genetic diversity using ERIC-PCR. METHODS AND

resultsA seven-year prospective cross-sectional study (2019-2025) was conducted in a tertiary care hospital in Northeast India with samples collected from superficial and deep tissue infections. Phenotypic detection of MBL was performed using the combined disk test, followed by PCR-based detection of MBL (bla

conclusionThe co-occurrence of MBL and mcr genes in NFGNB strains highlights the threat of multidrug resistance. Continuous molecular surveillance, hospital infection control, and stringent antibiotic stewardship policy are necessary to limit the spread of resistant clones.

Indexed as

beta-LactamasesColistinGram-Negative BacteriaSoft Tissue InfectionsAcinetobacter baumanniiAnti-Bacterial AgentsCross-Sectional StudiesDrug Resistance, BacterialDrug Resistance, Multiple, BacterialGram-Negative Bacterial InfectionsHumansIndiaMicrobial Sensitivity TestsPhylogenyProspective StudiesPseudomonas aeruginosaAnti-Bacterial Agentsbeta-LactamasesColistinCarbapenemColistinERIC PCRmcr geneMetallo β lactamaseNDM

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.