ArticleClinical ophthalmology (Auckland, N.Z.)2026
Unilateral Orbital Lymphomas: A Structured Multidisciplinary Workflow for Diagnosis and Management.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Purpose: To describe a structured multidisciplinary workflow for the diagnosis and management of unilateral orbital lymphoma and to illustrate its clinical application through representative cases from a tertiary referral practice. Despite advances in orbital imaging and hematopathology, no standardized framework currently integrates clinical assessment, quantitative MRI parameters, immunohistochemical subtyping, and systemic staging into a reproducible diagnostic-therapeutic pathway. Patients and Methods: A stepwise workflow integrating clinical assessment, MRI with diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) measurement, histopathologic confirmation with immunohistochemistry (IHC), and Results: The workflow facilitated systematic evaluation across all cases. MRI consistently demonstrated characteristic features: well-circumscribed, homogeneously enhancing lesions molding to orbital structures, with mean ADC values of 0.55-0.70 × 10 Conclusions: The proposed workflow provides a reproducible framework for integrating clinical, radiologic, and histopathologic data in orbital lymphoma evaluation. Systematic application may support diagnostic accuracy, facilitate individualized staging, and inform evidence-based treatment selection, although prospective multicenter validation is needed before broader adoption. This methodology complements a recently accepted companion paper on unilateral orbital lesions, together providing a comprehensive resource for orbital disease assessment.
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