ArticleNeuropsychiatric disease and treatment2026
Risk-Stratified Tiered Intervention Among Chinese Clinical High-Risk for Psychosis Patients and Attenuated Negative Symptoms as a Predictor of 1-Year Psychosis Conversion: A Retrospective Propensity-Matched Real-World Cohort Study.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This retrospective propensity-score-matched real-world cohort study aimed to evaluate the clinical efficacy of risk stratification combined with tiered intervention in young Chinese patients at clinical high-risk (CHR) for psychosis, and to explore whether attenuated negative symptoms could independently predict 1-year conversion to overt psychosis. Methods: A total of 150 CHR patients receiving risk-stratified tiered management were enrolled as the intervention group, and 75 CHR patients receiving conventional routine care were matched as the control group via propensity-score matching (PSM). All participants completed standardized two-stage clinical screening, cranial MRI to exclude organic brain lesions, and systematic symptom and functional assessments. Logistic regression and receiver-operating-characteristic (ROC) curve analyses were performed to identify independent predictors of psychosis conversion, with a specific focus on attenuated negative symptoms. Primary outcomes included 1-year psychosis conversion rate, changes in global functioning, and treatment adherence. Results: After 1-year follow-up, the intervention group showed a significantly lower psychosis conversion rate (9.3% vs 20.0%, Conclusion: Risk stratification paired with tiered intervention reduced the risk of psychosis transition, improved global social functioning, and enhanced treatment adherence among Chinese CHR patients within this real-world cohort. Attenuated negative symptoms represent a reliable independent predictor of 1-year psychosis conversion and may be integrated into routine clinical risk assessment to support targeted early-intervention strategies for CHR populations.
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