ArticleJournal of pain research2026
The Relationship Among Pain, Intrinsic Capacity, and Fear of Movement in Patients with Knee Osteoarthritis: A Moderated Network Analysis.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Objective: To investigate the relationship between intrinsic capacity (IC) and fear of movement, and to clarify how pain modified the relationship between IC and fear of movement at the symptom-level in patients with knee osteoarthritis (KOA). Methods: In this cross-sectional observational study, 452 patients with KOA were recruited from a tertiary hospital in China. All participants completed validated self-report questionnaires to assess IC, pain, and fear of movement. Symptom-level network visualization and centrality analyses were conducted via moderated network analysis. The Johnson-Neyman technique was further applied to verify and quantify statistically significant moderated network edges. Results: In the network, "somatic focus" was identified as the most central symptom (Expected Influence = 1.71), with the strongest association observed between "somatic focus" and "vision" (r = 0.62). Johnson-Neyman analysis revealed that pain significantly moderated the relationship between IC and fear of movement, including the edge between "psychological well-being" and "somatic focus" (t = -3.241, p < 0.01), and between "cognition" and "activity avoidance" (t = -2.740, p < 0.01). Additionally, higher pain strengthened the positive association between "avoidance beliefs" and "somatic focus" (t = 4.574, p < 0.001). Conclusion: Higher pain levels were associated with weaker relationships between selected intrinsic capacity domains and fear-of-movement dimensions. Targeted interventions integrating improved IC and pain management may represent a viable strategy to reduce fear of movement in patients with KOA, which requires confirmation in future longitudinal and intervention studies.
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