Evidence map›Paper›PMID 42801137›Full record

ArticleJBMR plus2026

Creation and characterization of novel knock-in mouse models of hypophosphatasia.

Rena Okawa, Marin Ochiai, Hiroshi Kurosaka, Tamami Kadota, Misato Takagi, Yuto Suehiro, Hiroko Okawa, Shuhei Naka, Satoshi Yamaguchi, Shin-Ichi Horike and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rena OkawaDepartment of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0000-0002-8634-209X
Marin OchiaiDepartment of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0009-0004-6100-3827
Hiroshi KurosakaDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0000-0002-8956-5467
Tamami KadotaDepartment of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0009-0007-6613-0093
Misato TakagiDepartment of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0009-0004-9696-9891
Yuto SuehiroDepartment of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0009-0004-1161-1779
Hiroko OkawaDivision of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan.ORCID https://orcid.org/0009-0006-2922-3461
Shuhei NakaDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.ORCID https://orcid.org/0000-0003-3457-1971
Satoshi YamaguchiDepartment of Dental Biomaterials, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0000-0002-4661-8821
Shin-Ichi HorikeDivision of Integrated Omics Research, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa 920-8640, Japan.ORCID https://orcid.org/0000-0002-4256-9129
Takiko DaikokuDivision of Animal Disease Model, Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa 920-8640, Japan.ORCID https://orcid.org/0000-0002-6280-8502
Atsushi WatanabeDivision of Clinical Genetics, Kanazawa University Hospital, Kanazawa 920-8640, Japan.ORCID https://orcid.org/0000-0001-9143-3079
Michiyo Matsumoto-NakanoDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.ORCID https://orcid.org/0000-0003-0620-9780
Satoshi ImazatoDepartment of Dental Biomaterials, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0000-0003-3655-4809
Toshimi MichigamiDepartment of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Izumi 594-1101, Japan.ORCID https://orcid.org/0000-0003-4069-5508
Keiichi OzonoCenter for Promoting Treatment of Intractable Diseases, ISEIKAI International General Hospital, Osaka 530-0052, Japan.ORCID https://orcid.org/0000-0002-6517-8825
Takashi YamashiroDepartment of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0000-0002-4419-9643
Kazuhiko NakanoDepartment of Pediatric Dentistry, Graduate School of Dentistry, The University of Osaka, Suita 565-0871, Japan.ORCID https://orcid.org/0009-0008-7980-8278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypophosphatasia (HPP) is a rare inherited disorder caused by inactivating variants in the

Indexed as

alkaline phosphatasecementumearly exfoliation of primary teethhypomineralizationhypophosphatasia

Identifiers

PMID42801137
PMCPMC13615531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.