ArticleJBMR plus2026
Is direct oxidative damage of bone collagen associated with poor human cortical bone tissue fracture resistance?
Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The limitations of clinical X-ray-based tools and fracture risk assessment tools, such as FRAX, particularly for disease groups, including type 2 diabetes (T2D) and CKD, suggest that important determinants of bone fracture resistance are not assessed. One such determinant is the bone collagen network, whose nativity and connectivity contribute to cortical bone fracture resistance, but whose degradation mechanisms remain unclear. Oxidative damage to the collagen network, driven by oxidative stress, has been proposed as a contributing factor. Two pathways are recognized: an indirect pathway involving glycoxidation and advanced glycation end-product formation, examined in a precursor study, and a direct pathway, examined herein, involving protein fragmentation and amino acid side chain modifications, such as carbonylation. To investigate the direct pathway, bulk collagen carbonyl content (measured using a fluorescence-based assay and normalized to collagen content) and intact collagen α-chain content (the opposite of α-chain fragmentation and measured via α-chain band intensities using gel electrophoresis) were quantified ex vivo using cortical bone specimens from 80 human donors with and without T2D and/or CKD. Relationships with fracture toughness and other bone quality measures from a precursor study were assessed using Spearman correlations and multiple linear regression. Bulk collagen carbonyl content was not directly associated with collagen network connectivity or cortical bone fracture toughness. In contrast, intact collagen α-chain content emerged as an independent explanatory variable for stable crack-growth fracture toughness measures (adj-
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