ArticleCureus2026
Comparative Evaluation of Postoperative Pain Following Nonsurgical Root Canal Treatment Using Calcium Hydroxide, Bio-C Temp, and Odontopaste as Intracanal Medicaments: A Prospective Clinical Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
backgroundPostoperative pain remains one of the most common complications following nonsurgical root canal treatment, and the choice of intracanal medication may influence the severity and duration of postoperative discomfort. This study compared the effectiveness of calcium hydroxide, Bio-C Temp (Angelus Indústria de Produtos Odontológicos S.A., Londrina, Brazil), and Odontopaste (Australian Dental Manufacturing Pty. Ltd., Brisbane, QLD, Australia) in controlling postoperative pain. METHODOLOGY: This prospective clinical study was conducted on 180 participants who required nonsurgical root canal treatment and were equally divided into three groups (60, 33.3%, each): calcium hydroxide, Bio-C Temp, and Odontopaste. Root canal treatment was performed using a standardized protocol. Postoperative pain was assessed using a 100-mm visual analog scale (VAS) at 24 hours, 48 hours, 72 hours, and seven days. The secondary outcomes included analgesic consumption, time to first analgesic intake, interappointment flare-up, postoperative swelling, and percussion tenderness. Data were analyzed using one-way analysis of variance (ANOVA), Kruskal-Wallis test, chi-square test, linear mixed-effects model, Kaplan-Meier survival analysis, and multivariable linear regression, with statistical significance set at
resultsBaseline demographic and clinical characteristics were comparable among the three groups (all
conclusionsAll three intracanal medicaments effectively reduced postoperative pain after nonsurgical root canal treatment. However, Bio-C Temp demonstrated superior clinical performance, providing significantly lower pain scores, reduced analgesic consumption, delayed analgesic requirements, and fewer postoperative complications than calcium hydroxide and Odontopaste. Therefore, Bio-C Temp may be considered a promising intracanal medicament for improving postoperative patient comfort during endodontic treatment.
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