Evidence map›Paper›PMID 42800815›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Are premature infants with severe bronchopulmonary dysplasia at increased risk for atypical craniosynostosis?

Suzanne Greenleaf Martin, Christa Matrone, Mark Stephens, Thais Queliz Pena, Mary Schreck, Richard A Guerrero, Angela Zimmerman, Samer K Elbabaa, Ryan Jafrani, Brent Golden

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Suzanne Greenleaf MartinOrlando Health Children's Neurosciences, Pediatric Craniomaxillofacial Surgery 207 West Gore Street, Orlando, FL, USA. Suzanne.martin@orlandohealth.com.ORCID http://orcid.org/0009-0008-7073-097X
Christa Matrone *Orlando Health Winnie Palmer Hospital, Neonatology 83 West Miller Street, Orlando, FL, USA.
Mark Stephens *Orlando Health Winnie Palmer Hospital, Neonatology 83 West Miller Street, Orlando, FL, USA.
Thais Queliz Pena *Orlando Health Winnie Palmer Hospital, Neonatology 83 West Miller Street, Orlando, FL, USA.
Mary Schreck *Orlando Health Medical Group Pediatric Specialty Practice 60 West Gore Street, Orlando, FL, USA.ORCID http://orcid.org/0000-0002-9875-9941
Richard A Guerrero *Orlando Health Children's Neurosciences, Pediatric Craniomaxillofacial Surgery 207 West Gore Street, Orlando, FL, USA.
Angela Zimmerman *Orlando Health Children's Neurosciences, Pediatric Neurosurgery 100 West Gore Street, Orlando, FL, USA.
Samer K Elbabaa *Orlando Health Children's Neurosciences, Pediatric Neurosurgery 100 West Gore Street, Orlando, FL, USA.ORCID http://orcid.org/0000-0003-1733-1941
Ryan Jafrani *Orlando Health Children's Neurosciences, Pediatric Neurosurgery 100 West Gore Street, Orlando, FL, USA.
Brent Golden *Orlando Health Children's Neurosciences, Pediatric Craniomaxillofacial Surgery 207 West Gore Street, Orlando, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe an atypical pattern of secondary craniosynostosis observed in premature infants with severe bronchopulmonary dysplasia (BPD) who required prolonged high-pressure ventilation and tracheostomy. STUDY

designA single-center retrospective chart review of infants born between January 2020 and May 2025. Inclusion criteria were gestational age 22-28 weeks, severe BPD, tracheostomy placement, and radiologic variables from the medical record.

resultTen patients met inclusion criteria. The greatest 4-week rise in head circumference percentile was 43 ± 14 percentile points, exceeding concurrent changes in weight and length (P = 0.0023). The weighted mean sustained positive end-expiratory pressure was 10.6 cm H₂O.

conclusionExtremely premature infants with severe BPD requiring prolonged high-pressure mechanical ventilation may be vulnerable to a novel phenotype of atypical craniosynostosis marked by accelerated head circumference growth, craniosynostosis, and calvarial thickening. Prospective studies are needed to define ventilatory exposure thresholds, clarify mechanisms, and determine neurologic and surgical implications.

Identifiers

PMID42800815

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.