Evidence map›Paper›PMID 42800812›Full record

ArticleBritish journal of cancer2026

Small extracellular vesicles from the plasma of head and neck cancer patients induce dysfunctional T cell phenotypes.

Luisa Tengler, Edwin K Jackson, Karen Bieback, Ralph Röth, Stefanie Mellein, Johann Kern, Marie-Nicole Theodoraki, Julia Schütz, Lena Huber, Claudia Scherl and 3 more

Abstract read
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Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Luisa TenglerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. luisa.tengler@medma.uni-heidelberg.de.ORCID http://orcid.org/0000-0003-3388-698X
Edwin K JacksonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Karen BiebackInstitute of Transfusion Medicine and Immunology, German Red Cross Blood Service, Baden-Württemberg-Hessen, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Ralph RöthnCounter Core Facility, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.
Stefanie MelleinnCounter Core Facility, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.
Johann KernDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Marie-Nicole TheodorakiDepartment of Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5491-1593
Julia SchützDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Lena HuberDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Claudia ScherlDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Nicole RotterDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Annette Affolter *Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sonja Ludwig *Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 2270/1-1Deutsche Forschungsgemeinschaft (German Research Foundation) TH 2172/2-2
6 · The paper itself

Abstract

backgroundHead and neck cancer (HNC) is highly immunosuppressive. Despite advances with immune checkpoint (IC) inhibitors, many HNC patients fail to respond. Tumour-derived small extracellular vesicles (sEVs) may contribute to immune evasion and therapy resistance, possibly by altering T-cell phenotypes.

methodPlasma sEVs were isolated from HNC patient samples and controls via size-exclusion chromatography. The plasma sEVs were characterised and analysed for their effects on CD4⁺ and CD8⁺ T-cell function, IC levels and gene expression.

resultsHNC patient-derived sEVs inhibit CD4

conclusionsOur findings suggest that plasma sEVs contribute to systemic immune modulation in HNC by inducing dysfunctional T-cell phenotypes. The ability of plasma-derived sEVs to modulate IC expression on T cells underscores the need for further investigation into their relevance for immunotherapeutic strategies in HNC.

Identifiers

PMID42800812

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