Evidence map›Paper›PMID 42800809›Full record

ArticleCell death & disease2026

Galectin-3 restrains T cell-driven inflammation in the testis and epididymis.

Hiba Hasan, Kimberly Jandel, Eva Wahle, Gabriela Michel, Linda Kreyling, Vishnu Kumar, Tara Procida-Kowalski, Sudhanshu Bhushan, Michaela Frolikova, Jens Rosellen and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Hiba HasanInstitute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany.
Kimberly JandelInstitute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany.
Eva WahleInstitute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany.
Gabriela MichelInstitute for Clinical Immunology, Transfusion Medicine and Hemostaseology, JLU cDeeP Core Facility, Justus-Liebig-University Giessen, Giessen, Germany.
Linda KreylingInstitute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany.
Vishnu KumarBiomedical Informatics and Systems Medicine Science Unit for Basic and Clinical Medicine, Justus Liebig University of Giessen, Giessen, Germany.
Tara Procida-KowalskiBiomedical Informatics and Systems Medicine Science Unit for Basic and Clinical Medicine, Justus Liebig University of Giessen, Giessen, Germany.
Sudhanshu BhushanInstitute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0002-9088-8108
Michaela FrolikovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, Vestec, Czech Republic.
Jens RosellenHessian Centre of Reproductive Medicine, Justus Liebig University of Giessen, Giessen, Germany.
Thorsten DiemerDepartment of Urology, Paediatric Urology and Andrology, Justus Liebig University of Giessen, Giessen, Germany.
Katerina KomrskovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences, Vestec, Czech Republic.
Marek BartkuhnBiomedical Informatics and Systems Medicine Science Unit for Basic and Clinical Medicine, Justus Liebig University of Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0001-6872-9082
Martin SpeckmannInstitute for Clinical Immunology, Transfusion Medicine and Hemostaseology, JLU cDeeP Core Facility, Justus-Liebig-University Giessen, Giessen, Germany.
Hans-Christian SchuppeHessian Centre of Reproductive Medicine, Justus Liebig University of Giessen, Giessen, Germany.
Daniela FietzHessian Centre of Reproductive Medicine, Justus Liebig University of Giessen, Giessen, Germany.
Christiane PleugerInstitute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany.
Andreas MeinhardtInstitute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany.ORCID http://orcid.org/0000-0003-3711-2746
Monika FijakInstitute of Anatomy and Cell Biology, Justus Liebig University of Giessen, Giessen, Germany. monika.fijak@anatomie.med.uni-giessen.de.ORCID http://orcid.org/0000-0002-7384-3872

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) FI 1801/5-1
6 · The paper itself

Abstract

Galectin-3 (Gal-3) is a pleiotropic molecule involved in immune regulation and tissue homeostasis. While it has been implicated in reproductive tissue function, its role in shaping immune cell dynamics within the testis and epididymis remains incompletely defined. Here, we investigated the function of Gal-3 in the testis and epididymis under steady-state and inflammatory conditions, to determine its contribution to inflammatory responses and tissue damage. In both murine and human tissues, Gal-3 frequency and staining intensity increased along the testicular-epididymal axis, with the highest proportion of Gal-3

Indexed as

EpididymisGalectin 3InflammationTestisT-LymphocytesAnimalsHumansMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutGalectin 3

Identifiers

PMID42800809
PMCPMC13615981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.