ArticleBMJ open gastroenterology2026
Prevalence of intestinal spirochaetosis in serrated polyposis syndrome compared with other colorectal polyp conditions: a case-control study in Japan.
Article in BMJ open gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSerrated polyposis syndrome (SPS) is the most common form of colorectal polyposis syndrome. Most SPS cases are sporadic, and the environmental factors underlying its pathogenesis remain poorly defined. Intestinal spirochaetosis (IS), an infection of the colonic epithelium by
methodsIn this retrospective case-control study at two centres in Japan, IS prevalence was assessed in 64 patients with SPS and 382 non-SPS controls who underwent colonoscopic polypectomy. Controls were classified as having only conventional adenomas (Ctrl-CA) or serrated polyps not meeting the diagnostic criteria of SPS (Ctrl-SP).
resultsHistologically confirmed IS was detected in 12/64 (18.8%) SPS cases and 6/382 (1.6%) controls (OR 14.5, 95% CI 5.2 to 40.2; p<0.001). IS prevalence increased stepwise across Ctrl-CA, Ctrl-SP and SPS groups (1/274 (0.4%), 5/108 (4.6%) and 12/64 (18.8%), respectively; OR 6.5, 95% CI 3.1 to 13.8; p for trend <0.001). Among the 12 IS-positive SPS cases, all had a history of cigarette smoking and altered bowel habits were common. Furthermore, IS detection rates did not differ based on anatomical locations of polyps, but considerable intraindividual variability was observed across serial colonoscopies, suggesting possible episodes of clearance and reinfection. Real-time PCR and sequencing analyses demonstrated that all IS-positive cases were attributable to
conclusionsThis study reveals a novel association between IS and SPS with distinct clinical characteristics in Japan. Considering the retrospective design and small sample size from a single geographic region, further investigation is required to clarify the significance and generalisability of this association.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.